Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2993159 | 296 | 62 | Q99836(MYD88_HUMAN) | RecName: Full=Myeloid differentiation primary response protein MyD88 ; |
QUERYSEQ |
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTL DDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP |
All | 153600 Macroglobulinemia, Waldenstrom, 1 (WM1) | 612260 Immunodeficiency 68 (IMD68) | US (uncertain significance) | ||
Number of sites | 296 | 1 | 2 | 14 | |
Buired or Exposed | Buried | 42.1 (%) [107] | 100.0 (%) [1] | 50.0 (%) [1] | 84.6 (%) [11] |
Exposed | 57.9 (%) [147] | 0.0 (%) [0] | 50.0 (%) [1] | 15.4 (%) [2] | |
Ave relacc | 33.3 % | 0.0 % | 18.8 % | 17.0 % | |
SD relacc | 28.58 % | 0.00 % | 17.14 % | 19.55 % | |
Contact Mol | hetero | 9.1 (%) [27] | 100.0 (%) [1] | 0.0 (%) [0] | 28.6 (%) [4] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
metal | 1.4 (%) [4] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 38.5 (%) [114] | 100.0 (%) [1] | 50.0 (%) [1] | 71.4 (%) [10] | |
precipitant | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
Number of variants | 17 | 1 | 2 | 15 | |
N_Freq(AAvariant)==0 % | 100.0 % [1] | 100.0 % [2] | 66.7 % [10] | ||
N_Freq(AAvariant)>0 % | 0.0 % [0] | 0.0 % [0] | 33.3 % [5] | ||
Ave Freq(AAvariant) | 0.0 % | 0.0 % | 4.1 % | ||
SD Freq(AAvariant) | 0.00 % | 0.00 % | 9.08 % |
1 sites | 252 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
252 | L | E | b | 0.0 | 2js7_A | hetero homo | LITV |
DOMAIN /note="TIR" DOMAIN /note="TIR" | L->P:(0.0 %):US Macroglobulinemia, Waldenstrom, 1 (WM1) dbSNP:rs3879072 [MIM:153600] |
2 sites | 93,196 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
93 | L | H | b | 1.7 | 6i3n_M | L |
DOMAIN /note="Death" DOMAIN /note="Death" | L->P:(0.0 %):LP/P Immunodeficiency 68 (IMD68) dbSNP:rs1378530 [MIM:612260] | |
196 | R | e | 36.0 | 2js7_A | homo | R |
MUTAGEN /note="R->A: Reduced interaction with TIRAP, and strongly reduced activity. Strongly reduced interaction with TIRAP; when associated with A-288." DOMAIN /note="TIR" MUTAGEN /note="R->A: Reduced interaction with TIRAP, and strongly reduced activity. Strongly reduced interaction with TIRAP; when associated with A-288." DOMAIN /note="TIR" | R->C:(0.0 %):LP/P Immunodeficiency 68 (IMD68) dbSNP:rs1378530 [MIM:612260] |
14 sites | 34,39,98,136,178,204,205,206,207,209,219,230,252,281 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
34 | S | H | b | 5.5 | 6i3n_M | hetero IRAK4_HUMAN homo | SGC |
S->Y:(0.0 %):US - dbSNP:rs1319438 | |
39 | V | S | e | 62.0 | 6i3n_M | hetero IRAK4_HUMAN homo | PV |
V->M:(0.0 %):US - dbSNP:rs7703876 | |
98 | R | b | 17.0 | 6i3n_M | hetero IRAK4_HUMAN homo | R |
DOMAIN /note="Death" DOMAIN /note="Death" | R->C:(0.0 %):US - dbSNP:rs199396 | |
136 | S | - | - | - | - | SA |
REGION /note="Intermediate domain" REGION /note="Intermediate domain" | S->G:(0.0 %):US -;S->I:(0.0 %):US - | |
178 | M | H | b | 0.0 | 2js7_A | MLIT |
DOMAIN /note="TIR" DOMAIN /note="TIR" | M->I:(19.0 %):US - dbSNP:rs4128511 | |
204 | V | b | 16.0 | 2js7_A | homo | VITLMAGSDEFKNPQRY |
DOMAIN /note="TIR" DOMAIN /note="TIR" | V->F:(1.0 %):US - dbSNP:rs7769954 | |
205 | W | b | 17.5 | 2js7_A | homo | VWIFSTRQADEGKLNPY |
DOMAIN /note="TIR" DOMAIN /note="TIR" | W->R:(5.0 %):US - | |
206 | S | b | 7.0 | 2js7_A | homo | DSEAT |
DOMAIN /note="TIR" DOMAIN /note="TIR" | S->C:(0.0 %):US - | |
207 | I | b | 7.6 | 2js7_A | homo | INELVP |
DOMAIN /note="TIR" DOMAIN /note="TIR" | I->T:(0.0 %):US - | |
209 | S | G | e | 58.6 | 2js7_A | homo | SAQIVHLDG |
DOMAIN /note="TIR" DOMAIN /note="TIR" | S->R:(0.0 %):US - |
219 | M | E | b | 0.0 | 2js7_A | TLMVADEGIKNPRS |
DOMAIN /note="TIR" DOMAIN /note="TIR" | M->T:(33.0 %):US - | |
230 | S | S | b | 18.0 | 2js7_A | homo | SDRGN |
DOMAIN /note="TIR" DOMAIN /note="TIR" | S->N:(4.0 %):US - dbSNP:rs1353791 |
252 | L | E | b | 0.0 | 2js7_A | hetero homo | LITV |
DOMAIN /note="TIR" DOMAIN /note="TIR" | L->P:(0.0 %):US Macroglobulinemia, Waldenstrom, 1 (WM1) dbSNP:rs3879072 [MIM:153600] |
281 | T | T | b | 12.3 | 2js7_A | TQGSLHA |
DOMAIN /note="TIR" DOMAIN /note="TIR" | T->P:(0.0 %):US - |