Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2932749 | 515 | 12 | P48551(INAR2_HUMAN) | RecName: Full=Interferon alpha/beta receptor 2; Short=IFN-R-2; Short=IFN-alpha binding protein; Short=IFN-alpha/beta receptor 2;AltName: Full=Interferon alpha binding protein;AltName: Full=Type I interferon receptor 2;Flags: Precursor; |
QUERYSEQ |
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINV MVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLS SHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR |
All | LB/B (likely benign or benign) | US (uncertain significance) | ||
Number of sites | 515 | 14 | 1 | |
Buired or Exposed | Buried | 37.6 (%) [79] | 0.0 (%) [0] | 0.0 (%) [0] |
Exposed | 62.4 (%) [131] | 100.0 (%) [4] | 100.0 (%) [1] | |
Ave relacc | 36.1 % | 59.4 % | 54.8 % | |
SD relacc | 29.40 % | 15.86 % | 0.00 % | |
Contact Mol | hetero | 7.6 (%) [39] | 14.3 (%) [2] | 0.0 (%) [0] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
metal | 1.6 (%) [8] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
precipitant | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
Number of variants | 15 | 14 | 1 | |
N_Freq(AAvariant)==0 % | 57.1 % [8] | 100.0 % [1] | ||
N_Freq(AAvariant)>0 % | 42.9 % [6] | 0.0 % [0] | ||
Ave Freq(AAvariant) | 12.6 % | 0.0 % | ||
SD Freq(AAvariant) | 22.04 % | 0.00 % |
14 sites | 8,10,37,73,196,215,283,295,318,324,346,362,385,450 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
8 | F | - | - | - | - | SVF |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | F->S:(44.0 %):LB/B - dbSNP:rs2229207 | |
10 | F | - | - | - | - | ILF |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | F->V:(0.0 %):LB/B - dbSNP:rs1051393 | |
37 | E | e | 36.7 | 2hym_A | E |
TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" | E->Q:(0.0 %):LB/B - dbSNP:rs2010033 | ||
73 | M | T | e | 66.7 | 2hym_A | hetero IFNA2_HUMAN Q86UP4_HUMAN IFNW1_HUMAN | M |
TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" | M->V:(0.0 %):LB/B - dbSNP:rs1428501 |
196 | I | E | e | 54.4 | 2hym_A | VI |
TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" | I->V:(75.0 %):LB/B - dbSNP:rs1786022 | |
215 | S | S | e | 79.7 | 2hym_A | hetero IFNA2_HUMAN | KSLADEGIPRTVCFHMNQY |
TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" | S->G:(2.0 %):LB/B - dbSNP:rs7476057 |
283 | H | - | - | - | - | YRH |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | H->R:(31.0 %):LB/B - dbSNP:rs7635080 | |
295 | P | - | - | - | - | P |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | P->L:(0.0 %):LB/B - dbSNP:rs7597449 | |
318 | Y | - | - | - | - | Y |
MUTAGEN /note="Y->F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F- 316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337." ECO:0000269|PubMed:12105218" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" MUTAGEN /note="Y->F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F- 316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337." ECO:0000269|PubMed:12105218" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" | Y->C:(0.0 %):LB/B - dbSNP:rs7565715 | |
324 | S | - | - | - | - | SI |
REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" | S->N:(0.0 %):LB/B - dbSNP:rs2014112 | |
346 | P | - | - | - | - | PAGLSDEFIKNQRTVY |
REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" | P->S:(2.0 %):LB/B - dbSNP:rs1485198 | |
362 | P | - | - | - | - | PCE |
REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" | P->S:(0.0 %):LB/B - dbSNP:rs1441207 | |
385 | P | - | - | - | - | PL |
REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" | P->L:(22.0 %):LB/B - dbSNP:rs1231284 | |
450 | S | - | - | - | - | SP |
TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic" | S->L:(0.0 %):LB/B - dbSNP:rs8667333 |
1 sites | 138 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
138 | E | E | e | 54.8 | 2hym_A | EK |
TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" | E->V:(0.0 %):US - |