HOMCOS:

		Contact Molecules for Homologous Proteins
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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

2932749

515

P48551(INAR2_HUMAN)

RecName: Full=Interferon alpha/beta receptor 2; Short=IFN-R-2; Short=IFN-alpha binding protein; Short=IFN-alpha/beta receptor 2;AltName: Full=Interferon alpha binding protein;AltName: Full=Type I interferon receptor 2;Flags: Precursor;

QUERYSEQ

MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINV
MVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLS
SHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

		All	LB/B (likely benign or benign)	US (uncertain significance)
Number of sites		515	14	1
Buired or Exposed	Buried	37.6 (%) [79]	0.0 (%) [0]	0.0 (%) [0]
Buired or Exposed	Exposed	62.4 (%) [131]	100.0 (%) [4]	100.0 (%) [1]
Ave relacc		36.1 %	59.4 %	54.8 %
SD relacc		29.40 %	15.86 %	0.00 %
Contact Mol	hetero	7.6 (%) [39]	14.3 (%) [2]	0.0 (%) [0]
	nucleotide	0.0 (%) [0]	0.0 (%) [0]	0.0 (%) [0]
	compound	0.0 (%) [0]	0.0 (%) [0]	0.0 (%) [0]
	metal	1.6 (%) [8]	0.0 (%) [0]	0.0 (%) [0]
	otherpoly	0.0 (%) [0]	0.0 (%) [0]	0.0 (%) [0]
	homo	0.0 (%) [0]	0.0 (%) [0]	0.0 (%) [0]
	precipitant	0.0 (%) [0]	0.0 (%) [0]	0.0 (%) [0]
Number of variants		15	14	1
N_Freq(AAvariant)==0 %			57.1 % [8]	100.0 % [1]
N_Freq(AAvariant)>0 %			42.9 % [6]	0.0 % [0]
Ave Freq(AAvariant)			12.6 %	0.0 %
SD Freq(AAvariant)			22.04 %	0.00 %

Site Table for OMIM:LB/B [14 variants]

14 sites

8,10,37,73,196,215,283,295,318,324,346,362,385,450

  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.

n	a	s	e	acc	pdb	contact_mols	observed aa	feature table	variant
8	F	-	-	-	-		SVF	SIGNAL DISORDER predicted by DISOPRED SIGNAL	F->S:(44.0 %):LB/B - dbSNP:rs2229207
10	F	-	-	-	-		ILF	SIGNAL DISORDER predicted by DISOPRED SIGNAL	F->V:(0.0 %):LB/B - dbSNP:rs1051393
37	E		e	36.7	2hym_A		E	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	E->Q:(0.0 %):LB/B - dbSNP:rs2010033
73	M	T	e	66.7	2hym_A	hetero IFNA2_HUMAN Q86UP4_HUMAN IFNW1_HUMAN	M	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	M->V:(0.0 %):LB/B - dbSNP:rs1428501
196	I	E	e	54.4	2hym_A		VI	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	I->V:(75.0 %):LB/B - dbSNP:rs1786022
215	S	S	e	79.7	2hym_A	hetero IFNA2_HUMAN	KSLADEGIPRTVCFHMNQY	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	S->G:(2.0 %):LB/B - dbSNP:rs7476057
283	H	-	-	-	-		YRH	TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"	H->R:(31.0 %):LB/B - dbSNP:rs7635080
295	P	-	-	-	-		P	TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"	P->L:(0.0 %):LB/B - dbSNP:rs7597449
318	Y	-	-	-	-		Y	MUTAGEN /note="Y->F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F- 316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337." ECO:0000269\|PubMed:12105218" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" MUTAGEN /note="Y->F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F- 316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337." ECO:0000269\|PubMed:12105218" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic"	Y->C:(0.0 %):LB/B - dbSNP:rs7565715
324	S	-	-	-	-		SI	REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic"	S->N:(0.0 %):LB/B - dbSNP:rs2014112
346	P	-	-	-	-		PAGLSDEFIKNQRTVY	REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic"	P->S:(2.0 %):LB/B - dbSNP:rs1485198
362	P	-	-	-	-		PCE	REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic"	P->S:(0.0 %):LB/B - dbSNP:rs1441207
385	P	-	-	-	-		PL	REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic"	P->L:(22.0 %):LB/B - dbSNP:rs1231284
450	S	-	-	-	-		SP	TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"	S->L:(0.0 %):LB/B - dbSNP:rs8667333

Site Table for OMIM:US [1 variants]

1 sites

138

  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.

n	a	s	e	acc	pdb	contact_mols	observed aa	feature table	variant
138	E	E	e	54.8	2hym_A		EK	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	E->V:(0.0 %):US -

Contact Molecules for Homologous Proteins

Sites by Variants[0.0 %]

Statistics of sites in view of Disease classification

Site Table for OMIM:LB/B [14 variants]

Site Table for OMIM:US [1 variants]