Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2752856 | 925 | 131 | O95786(RIGI_HUMAN) | RecName: Full=Antiviral innate immune response receptor RIG-I ;AltName: Full=ATP-dependent RNA helicase DDX58 ; EC=3.6.4.13 ;AltName: Full=DEAD box protein 58;AltName: Full=RIG-I-like receptor 1; Short=RLR-1;AltName: Full=RNA sensor RIG-I ;AltName: Full=Retinoic acid-inducible gene 1 protein; Short=RIG-1;AltName: Full=Retinoic acid-inducible gene I protein; Short=RIG-I; |
QUERYSEQ |
MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMA GAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELE QVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEK EQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG VQTLYSKWKDFHFEKIPFDPAEMSK |
All | 616298 Singleton-Merten syndrome 2 (SGMRT2) | LB/B (likely benign or benign) | ||
Number of sites | 925 | 2 | 2 | |
Buired or Exposed | Buried | 47.2 (%) [415] | 50.0 (%) [1] | 50.0 (%) [1] |
Exposed | 52.8 (%) [465] | 50.0 (%) [1] | 50.0 (%) [1] | |
Ave relacc | 28.5 % | 32.7 % | 42.0 % | |
SD relacc | 26.37 % | 26.65 % | 24.05 % | |
Contact Mol | hetero | 9.3 (%) [86] | 0.0 (%) [0] | 50.0 (%) [1] |
nucleotide | 10.6 (%) [98] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 3.9 (%) [36] | 50.0 (%) [1] | 0.0 (%) [0] | |
metal | 5.3 (%) [49] | 50.0 (%) [1] | 0.0 (%) [0] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 24.1 (%) [223] | 50.0 (%) [1] | 50.0 (%) [1] | |
precipitant | 11.0 (%) [102] | 100.0 (%) [2] | 0.0 (%) [0] | |
Number of variants | 4 | 2 | 2 | |
N_Freq(AAvariant)==0 % | 100.0 % [2] | 50.0 % [1] | ||
N_Freq(AAvariant)>0 % | 0.0 % [0] | 50.0 % [1] | ||
Ave Freq(AAvariant) | 0.0 % | 5.0 % | ||
SD Freq(AAvariant) | 0.00 % | 5.00 % |
2 sites | 268,373 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
268 | C | H | e | 59.3 | 7to0_A | compound ADP ANP precipitant | SLATCIM |
BINDING /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" DOMAIN /note="Helicase ATP-binding" REGION /note="Interaction with ZC3HAV1" BINDING /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" DOMAIN /note="Helicase ATP-binding" REGION /note="Interaction with ZC3HAV1" | C->F:(0.0 %):LP/P Singleton-Merten syndrome 2 (SGMRT2) dbSNP:rs7862048 [MIM:616298] |
373 | E | S | b | 6.0 | 7to0_A | metal MG homo precipitant | E |
MOTIF /note="DECH box" MUTAGEN /note="DECH->AACA: Loss of dsRNA-induced ATPase activity. No effect on ds-RNA binding. Changed RIG-I signaling pathway." DOMAIN /note="Helicase ATP-binding" REGION /note="Interaction with ZC3HAV1" MOTIF /note="DECH box" MUTAGEN /note="DECH->AACA: Loss of dsRNA-induced ATPase activity. No effect on ds-RNA binding. Changed RIG-I signaling pathway." DOMAIN /note="Helicase ATP-binding" REGION /note="Interaction with ZC3HAV1" | E->A:(0.0 %):LP/P Singleton-Merten syndrome 2 (SGMRT2) dbSNP:rs7862048 [MIM:616298] |
2 sites | 7,580 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
7 | R | H | e | 66.0 | 4a2w_A | hetero UBC_HUMAN RL40_HUMAN homo | RQ |
DOMAIN /note="CARD 1" DOMAIN /note="CARD 1" | R->C:(0.0 %):LB/B - dbSNP:rs1081383 |
580 | D | b | 17.9 | 7to0_A | DEAGKLQSTFRMNVHIPY |
REGION /note="Interaction with ZC3HAV1" REGION /note="Interaction with ZC3HAV1" | D->E:(10.0 %):LB/B - dbSNP:rs1721728 |