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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2711687 385 54 P35613(BASI_HUMAN) RecName: Full=Basigin ;AltName: Full=5F7;AltName: Full=Collagenase stimulatory factor;AltName: Full=Extracellular matrix metalloproteinase inducer; Short=EMMPRIN;AltName: Full=Hepatoma-associated antigen ; Short=HAb18G ;AltName: Full=Leukocyte activation antigen M6;AltName: Full=OK blood group antigen;AltName: Full=Tumor cell-derived collagenase stimulatory factor; Short=TCSF;AltName: CD_antigen=CD147;Flags: Precursor;
QUERYSEQ 
MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG
SKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR
CNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 385 8
Buired or ExposedBuried 22.9 (%) [78] 14.3 (%) [1]
Exposed 77.1 (%) [262] 85.7 (%) [6]
Ave relacc 39.2 % 46.4 %
SD relacc 24.02 % 16.96 %
Contact Molhetero 29.9 (%) [115] 37.5 (%) [3]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 5.7 (%) [22] 0.0 (%) [0]
metal 1.0 (%) [4] 0.0 (%) [0]
otherpoly 5.7 (%) [22] 0.0 (%) [0]
homo 26.2 (%) [101] 50.0 (%) [4]
precipitant 3.4 (%) [13] 0.0 (%) [0]
Number of variants 8 8
N_Freq(AAvariant)==0 % 12.5 % [1]
N_Freq(AAvariant)>0 % 87.5 % [7]
Ave Freq(AAvariant) 7.5 %
SD Freq(AAvariant) 7.86 %

Site Table for OMIM:LB/B [8 variants]

8 sites 13,16,26,152,176,206,208,269
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
13L---- 
LVFMA
 SIGNAL SIGNAL DISORDER predicted by DISOPRED L->V:(25.0 %):LB/B - dbSNP:rs2018506
16T e 60.9 2edj_A 
STAVYQGR
 SIGNAL SIGNAL DISORDER predicted by DISOPRED T->A:(15.0 %):LB/B - dbSNP:rs1155190
26VEe 56.7 3qr2_A homo 
AEILPRTVYDGKS
 V->F:(0.0 %):LB/B - dbSNP:rs1448246
152KEe 21.7 7da5_B hetero 
TSPAKREDQMNVLW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" K->N:(4.0 %):LB/B - dbSNP:rs14704
176VEe 59.3 7da5_B hetero homo 
SVRAKQELTFIGNPYM
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" V->L:(6.0 %):LB/B - dbSNP:rs2229662
206LSb 19.1 7da5_B homo 
LAVRTISDEKYGMNP
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" L->P:(1.0 %):LB/B - dbSNP:rs5591114
208ETe 47.2 7da5_B homo 
ENADPSKRHLQTGIV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" E->K:(5.0 %):LB/B - dbSNP:rs1048946
269GTe 59.5 7da5_B hetero 
GSPDKNHAVLFRTEIQ
 DOMAIN /note="Ig-like V-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like V-type" TOPO_DOM /note="Extracellular" G->V:(4.0 %):LB/B - dbSNP:rs1803203