Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2691701 | 207 | 1500 | P51149(RAB7A_HUMAN) | RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ; |
QUERYSEQ |
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIP YFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC |
All | 600882 Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) | LB/B (likely benign or benign) | ||
Number of sites | 207 | 4 | 1 | |
Buired or Exposed | Buried | 41.1 (%) [79] | 25.0 (%) [1] | 0.0 (%) [0] |
Exposed | 58.9 (%) [113] | 75.0 (%) [3] | 100.0 (%) [1] | |
Ave relacc | 32.9 % | 30.8 % | 56.1 % | |
SD relacc | 29.15 % | 16.91 % | 0.00 % | |
Contact Mol | hetero | 79.7 (%) [165] | 100.0 (%) [4] | 100.0 (%) [1] |
nucleotide | 4.3 (%) [9] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 54.1 (%) [112] | 75.0 (%) [3] | 100.0 (%) [1] | |
metal | 58.0 (%) [120] | 100.0 (%) [4] | 100.0 (%) [1] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 73.4 (%) [152] | 100.0 (%) [4] | 100.0 (%) [1] | |
precipitant | 72.9 (%) [151] | 100.0 (%) [4] | 100.0 (%) [1] | |
Number of variants | 5 | 4 | 1 | |
N_Freq(AAvariant)==0 % | 25.0 % [1] | 0.0 % [0] | ||
N_Freq(AAvariant)>0 % | 75.0 % [3] | 100.0 % [1] | ||
Ave Freq(AAvariant) | 1.0 % | 17.0 % | ||
SD Freq(AAvariant) | 0.71 % | 0.00 % |
4 sites | 129,157,161,162 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
![]() | L | S | e | 44.4 | ![]() |
hetero PI4KB_HUMAN RAB3I_HUMAN VIRA_SHIFL TNPO1_HUMAN XPO1_YEAST KA122_YEAST CSE1_YEAST O52121_ECOLX Q5WMC0_ECOLX PI4KB_BOVIN compound GDP GNP GTP GSP GCP CAG 6ZD BTB DBG G3D Y9Z VJ8 VJB metal UNX homo precipitant | LMIVKARCDEFHPQST |
L->F:(1.0 %):LP/P Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) dbSNP:rs1219090 [MIM:600882] | |
![]() | K | T | e | 41.0 | ![]() |
hetero PI4KB_HUMAN RAB3I_HUMAN RPGF4_MOUSE SOS1_HUMAN IMB1_YEAST RASK_HUMAN A2ASW3_MOUSE XPOT_SCHPO SHOC2_HUMAN IMB5_YEAST CSE1_YEAST XPO1_MOUSE IF5A1_HUMAN PI4KB_BOVIN KA122_YEAST ANKX_LEGPH IPO9_HUMAN compound GDP GNP GTP GCP GSP CAG 2UK 6ZD AGN GNH DBG G3D RSG Y9Z 2UH 2UJ VJ8 VJB metal CL K homo precipitant | KLARTMSEFIQV |
BINDING /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791" BINDING /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791" | K->N:(0.0 %):LP/P Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) dbSNP:rs1219090 [MIM:600882] |
![]() | N | S | e | 35.8 | ![]() |
hetero XPO1_YEAST RBP2_HUMAN TR120_YEAST IMB1_YEAST TNPO1_HUMAN XPOT_SCHPO IMB1_HUMAN TNPO3_HUMAN W7PTE1_YEASX ANKX_LEGPH IMB5_YEAST compound 17F GLC metal UNX CL homo precipitant | NGSHRTCDEKLQ |
N->T:(2.0 %):LP/P Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) dbSNP:rs1219090 [MIM:600882] | |
![]() | V | H | b | 2.0 | ![]() |
hetero YRB1_YEAST RBP2_HUMAN A0A6A5PZB5_YEASX IMB1_YEAST TNPO1_HUMAN NUP50_HUMAN RANG_HUMAN YRB2_YEAST metal CL UNX homo precipitant | VILFTAEKMY |
V->M:(1.0 %):LP/P Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) dbSNP:rs1219090 [MIM:600882] |
1 sites | 32 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
![]() | K | e | 56.1 | ![]() |
hetero YRB1_YEAST SOS1_HUMAN RBP2_HUMAN A0A6A5PZB5_YEASX KRIT1_HUMAN RANG_HUMAN 3BP5_HUMAN PP1A_HUMAN SEC2_YEAST RPGF4_MOUSE RASK_HUMAN RBP1_HUMAN IMB1_YEAST MYO5B_HUMAN RAF1_HUMAN SEC5_RAT Q9HBX6_HUMAN RASF5_MOUSE YRB2_YEAST PI4KB_HUMAN MYO5A_HUMAN G0SGS3_CHATD DRRA_LEGPN SIN1_HUMAN NUP50_HUMAN RGL2_HUMAN AB1IP_MOUSE TNPO3_HUMAN IF5A1_HUMAN PI4KB_BOVIN TLN1_MOUSE SHAN3_MOUSE ANKX_LEGPH PP1G_HUMAN IPO9_HUMAN compound GDP metal UNX MG NA ZN CO homo precipitant | ERKQTSAHDIGNPVCLMY |
K->E:(17.0 %):LB/B - dbSNP:rs1154975 |