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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2690321 904 29 O15455(TLR3_HUMAN) RecName: Full=Toll-like receptor 3 ;AltName: CD_antigen=CD283;Flags: Precursor;
QUERYSEQ 
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI
TLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ
EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQ
TEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All 613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) LB/B (likely benign or benign)US (uncertain significance)
Number of sites 904 1 7 2
Buired or ExposedBuried 45.2 (%) [326] 0.0 (%) [0] 33.3 (%) [2] 0.0 (%) [0]
Exposed 54.8 (%) [395] 100.0 (%) [1] 66.7 (%) [4] 100.0 (%) [1]
Ave relacc 27.6 % 25.6 % 35.4 % 41.4 %
SD relacc 24.41 % 0.00 % 29.62 % 0.00 %
Contact Molhetero 9.6 (%) [87] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
nucleotide 3.2 (%) [29] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
compound 6.6 (%) [60] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
metal 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
otherpoly 5.8 (%) [52] 0.0 (%) [0] 14.3 (%) [1] 0.0 (%) [0]
homo 4.0 (%) [36] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
precipitant 3.9 (%) [35] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
Number of variants 10 1 7 2
N_Freq(AAvariant)==0 % 0.0 % [0] 0.0 % [0] 0.0 % [0]
N_Freq(AAvariant)>0 % 100.0 % [1] 100.0 % [7] 100.0 % [2]
Ave Freq(AAvariant) 10.0 % 6.6 % 3.0 %
SD Freq(AAvariant) 0.00 % 6.86 % 2.00 %

Site Table for OMIM:613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) [1 variants]

1 sites 554
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
554P e 25.6 7c76_A 
PSADELGITCKNQRVFYHMW
 TOPO_DOM /note="Lumenal" TOPO_DOM /note="Lumenal" P->S:(10.0 %):LP/P Immunodeficiency 83, susceptibility to viral infections (IMD83) dbSNP:rs1214344 [MIM:613002]

Site Table for OMIM:LB/B [7 variants]

7 sites 251,284,307,412,732,737,867
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
251R e 39.9 7c76_A otherpoly 
RKLETNQDSAHPVGFIMY
 REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" R->G:(3.0 %):LB/B - dbSNP:rs7800513
284NSb 0.6 7c76_A 
NEDTKSACGLMQRVHI
 REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" N->I:(1.0 %):LB/B - dbSNP:rs5743316
307YSe 31.7 7c76_A 
HGNLSFQAREIYDKVPMTW
 REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" Y->D:(3.0 %):LB/B - dbSNP:rs5743317
412LEb 1.7 7c76_A 
LIVFAPRYEGKMNQSTW
 REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" L->F:(4.0 %):LB/B - dbSNP:rs3775291
732FHe 86.6 8ar1_A 
FYLCMIKAH
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" F->L:(14.0 %):LB/B - dbSNP:rs9885865
737S e 51.6 8ar1_A 
TSCAMRGILKQYDENPV
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" S->T:(20.0 %):LB/B - dbSNP:rs5743318
867R---- 
RLYADEFGIKNPQSTV
 DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" R->Q:(1.0 %):LB/B - dbSNP:rs1997689

Site Table for OMIM:US [2 variants]

2 sites 134,870
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
134S e 41.4 7c76_A 
SKNRQALPTEGHCDFMVIY
 REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" S->P:(5.0 %):US -
870M---- 
LIYFMV
 DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" M->V:(1.0 %):US -