Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2690321 | 904 | 41 | O15455(TLR3_HUMAN) | RecName: Full=Toll-like receptor 3 ;AltName: CD_antigen=CD283;Flags: Precursor; |
QUERYSEQ |
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI TLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQ TEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK NSVH |
All | 613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) | LB/B (likely benign or benign) | US (uncertain significance) | ||
Number of sites | 904 | 1 | 7 | 2 | |
Buired or Exposed | Buried | 45.2 (%) [326] | 0.0 (%) [0] | 33.3 (%) [2] | 0.0 (%) [0] |
Exposed | 54.8 (%) [395] | 100.0 (%) [1] | 66.7 (%) [4] | 100.0 (%) [1] | |
Ave relacc | 27.6 % | 25.6 % | 35.4 % | 41.4 % | |
SD relacc | 24.41 % | 0.00 % | 29.62 % | 0.00 % | |
Contact Mol | hetero | 10.1 (%) [91] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] |
nucleotide | 3.7 (%) [33] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 8.3 (%) [75] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
metal | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 7.5 (%) [68] | 0.0 (%) [0] | 28.6 (%) [2] | 0.0 (%) [0] | |
homo | 4.9 (%) [44] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
precipitant | 3.9 (%) [35] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
Number of variants | 10 | 1 | 7 | 2 | |
N_Freq(AAvariant)==0 % | 0.0 % [0] | 0.0 % [0] | 0.0 % [0] | ||
N_Freq(AAvariant)>0 % | 100.0 % [1] | 100.0 % [7] | 100.0 % [2] | ||
Ave Freq(AAvariant) | 10.0 % | 6.6 % | 3.0 % | ||
SD Freq(AAvariant) | 0.00 % | 6.86 % | 2.00 % |
1 sites | 554 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
554 | P | e | 25.6 | 7c76_A | PSADELGITCKNQRVFYHMW |
TOPO_DOM /note="Lumenal" TOPO_DOM /note="Lumenal" | P->S:(10.0 %):LP/P Immunodeficiency 83, susceptibility to viral infections (IMD83) dbSNP:rs1214344 [MIM:613002] |
7 sites | 251,284,307,412,732,737,867 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
251 | R | e | 39.9 | 7c76_A | otherpoly | RKLETNQDSAHPVGFIMY |
REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" | R->G:(3.0 %):LB/B - dbSNP:rs7800513 | |
284 | N | S | b | 0.6 | 7c76_A | NEDTKSACGLMQRVHI |
REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" | N->I:(1.0 %):LB/B - dbSNP:rs5743316 | |
307 | Y | S | e | 31.7 | 7c76_A | HGNLSFQAREIYDKVPMTW |
REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" | Y->D:(3.0 %):LB/B - dbSNP:rs5743317 | |
412 | L | E | b | 1.7 | 7c76_A | otherpoly | LIVFAPRYEGKMNQSTW |
REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" | L->F:(4.0 %):LB/B - dbSNP:rs3775291 |
732 | F | H | e | 86.6 | 8ar1_A | FYLCMIKAH |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | F->L:(14.0 %):LB/B - dbSNP:rs9885865 | |
737 | S | e | 51.6 | 8ar1_A | TSCAMRGILKQYDENPV |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | S->T:(20.0 %):LB/B - dbSNP:rs5743318 | ||
867 | R | - | - | - | - | RLYADEFGIKNPQSTV |
DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" | R->Q:(1.0 %):LB/B - dbSNP:rs1997689 |
2 sites | 134,870 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
134 | S | e | 41.4 | 7c76_A | SKNRQALPTEGHCDFMVIY |
REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" | S->P:(5.0 %):US - | ||
870 | M | - | - | - | - | LIYFMV |
DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" | M->V:(1.0 %):US - |