Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2690321 | 904 | 756 | O15455(TLR3_HUMAN) | RecName: Full=Toll-like receptor 3 ;AltName: CD_antigen=CD283;Flags: Precursor; |
QUERYSEQ |
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI TLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQ TEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK NSVH |
All | 613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) | LB/B (likely benign or benign) | US (uncertain significance) | ||
Number of sites | 904 | 1 | 7 | 2 | |
Buired or Exposed | Buried | 44.2 (%) [389] | 0.0 (%) [0] | 42.9 (%) [3] | 50.0 (%) [1] |
Exposed | 55.8 (%) [491] | 100.0 (%) [1] | 57.1 (%) [4] | 50.0 (%) [1] | |
Ave relacc | 29.1 % | 25.6 % | 30.4 % | 23.6 % | |
SD relacc | 25.37 % | 0.00 % | 30.00 % | 17.83 % | |
Contact Mol | hetero | 48.8 (%) [441] | 0.0 (%) [0] | 57.1 (%) [4] | 50.0 (%) [1] |
nucleotide | 15.0 (%) [136] | 0.0 (%) [0] | 14.3 (%) [1] | 0.0 (%) [0] | |
compound | 46.2 (%) [418] | 100.0 (%) [1] | 42.9 (%) [3] | 50.0 (%) [1] | |
metal | 15.0 (%) [136] | 0.0 (%) [0] | 14.3 (%) [1] | 50.0 (%) [1] | |
otherpoly | 33.5 (%) [303] | 100.0 (%) [1] | 57.1 (%) [4] | 50.0 (%) [1] | |
homo | 43.0 (%) [389] | 0.0 (%) [0] | 14.3 (%) [1] | 50.0 (%) [1] | |
precipitant | 43.3 (%) [391] | 0.0 (%) [0] | 14.3 (%) [1] | 50.0 (%) [1] | |
Number of variants | 10 | 1 | 7 | 2 | |
N_Freq(AAvariant)==0 % | 0.0 % [0] | 0.0 % [0] | 0.0 % [0] | ||
N_Freq(AAvariant)>0 % | 100.0 % [1] | 100.0 % [7] | 100.0 % [2] | ||
Ave Freq(AAvariant) | 10.0 % | 6.6 % | 3.0 % | ||
SD Freq(AAvariant) | 0.00 % | 6.86 % | 2.00 % |
1 sites | 554 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
554 | P | e | 25.6 | 7c76_A | compound NAG otherpoly | PSADELGITCKNQRVFYHMW |
TOPO_DOM /note="Lumenal" TOPO_DOM /note="Lumenal" | P->S:(10.0 %):LP/P Immunodeficiency 83, susceptibility to viral infections (IMD83) dbSNP:rs1214344 [MIM:613002] |
7 sites | 251,284,307,412,732,737,867 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
251 | R | e | 39.9 | 7c76_A | hetero CIF2_ARATH RSPO1_HUMAN compound NAG otherpoly precipitant | RKLETNQDSAHPVGFIMY |
REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" | R->G:(3.0 %):LB/B - dbSNP:rs7800513 | |
284 | N | S | b | 0.6 | 7c76_A | hetero TGFB1_HUMAN compound NAG otherpoly | NEDTKSACGLMQRVHI |
REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" | N->I:(1.0 %):LB/B - dbSNP:rs5743316 |
307 | Y | S | e | 31.7 | 7c76_A | hetero LY96_HUMAN TGFB1_HUMAN CIF2_ARATH Q16J57_AEDAE CADH1_HUMAN nucleotide compound RX8 MBL UPT M4D C09 D87 HB2 M0A IDQ CU8 DY3 U57 QLH I6A JRI YHG D80 XG1 7VF 7VL I5N metal ZN otherpoly homo | HGNLSFQAREIYDKVPMTW |
REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" | Y->D:(3.0 %):LB/B - dbSNP:rs5743317 |
412 | L | E | b | 1.7 | 7c76_A | hetero LY86_MOUSE otherpoly | LIVFAPRYEGKMNQSTW |
REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" | L->F:(4.0 %):LB/B - dbSNP:rs3775291 |
732 | F | H | e | 86.6 | 8ar1_A | FYLCMIKAH |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | F->L:(14.0 %):LB/B - dbSNP:rs9885865 | |
737 | S | e | 51.6 | 8ar1_A | TSCAMRGILKQYDENPV |
TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" | S->T:(20.0 %):LB/B - dbSNP:rs5743318 | ||
867 | R | H | b | 0.6 | 2j67_A | RLYADEFGIKNPQSTV |
DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" | R->Q:(1.0 %):LB/B - dbSNP:rs1997689 |
2 sites | 134,870 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
134 | S | e | 41.4 | 7c76_A | hetero UNC5D_RAT F1LW30_RAT compound NAG metal CL otherpoly homo precipitant | SKNRQALPTEGHCDFMVIY |
REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" | S->P:(5.0 %):US - | |
870 | M | H | b | 5.7 | 3j0a_A | LIYFMV |
DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" | M->V:(1.0 %):US - |