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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2690321 904 860 O15455(TLR3_HUMAN) RecName: Full=Toll-like receptor 3 ;AltName: CD_antigen=CD283;Flags: Precursor;
QUERYSEQ 
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI
TLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ
EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQ
TEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
NSVH
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All 613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) LB/B (likely benign or benign)US (uncertain significance)
Number of sites 904 1 7 2
Buired or ExposedBuried 43.9 (%) [388] 0.0 (%) [0] 42.9 (%) [3] 50.0 (%) [1]
Exposed 56.1 (%) [495] 100.0 (%) [1] 57.1 (%) [4] 50.0 (%) [1]
Ave relacc 29.1 % 25.6 % 30.4 % 23.6 %
SD relacc 25.28 % 0.00 % 30.00 % 17.83 %
Contact Molhetero 51.5 (%) [466] 0.0 (%) [0] 57.1 (%) [4] 50.0 (%) [1]
nucleotide 15.0 (%) [136] 0.0 (%) [0] 14.3 (%) [1] 0.0 (%) [0]
compound 51.1 (%) [462] 100.0 (%) [1] 42.9 (%) [3] 50.0 (%) [1]
metal 15.0 (%) [136] 0.0 (%) [0] 14.3 (%) [1] 50.0 (%) [1]
otherpoly 37.5 (%) [339] 100.0 (%) [1] 57.1 (%) [4] 50.0 (%) [1]
homo 52.0 (%) [470] 0.0 (%) [0] 14.3 (%) [1] 50.0 (%) [1]
precipitant 47.2 (%) [427] 0.0 (%) [0] 14.3 (%) [1] 50.0 (%) [1]
Number of variants 10 1 7 2
N_Freq(AAvariant)==0 % 0.0 % [0] 0.0 % [0] 0.0 % [0]
N_Freq(AAvariant)>0 % 100.0 % [1] 100.0 % [7] 100.0 % [2]
Ave Freq(AAvariant) 10.0 % 6.6 % 3.0 %
SD Freq(AAvariant) 0.00 % 6.86 % 2.00 %

Site Table for OMIM:613002 Immunodeficiency 83, susceptibility to viral infections (IMD83) [1 variants]

1 sites 554
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
554P e 25.6 7c76_A compound NAG otherpoly 
PSADELGITCKNQRVFYHMW
 TOPO_DOM /note="Lumenal" TOPO_DOM /note="Lumenal" P->S:(10.0 %):LP/P Immunodeficiency 83, susceptibility to viral infections (IMD83) dbSNP:rs1214344 [MIM:613002]

Site Table for OMIM:LB/B [7 variants]

7 sites 251,284,307,412,732,737,867
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
251R e 39.9 7c76_A hetero CIF2_ARATH RSPO1_HUMAN compound NAG otherpoly precipitant 
RKLETNQDSAHPVGFIMY
 REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 9" TOPO_DOM /note="Lumenal" R->G:(3.0 %):LB/B - dbSNP:rs7800513
284NSb 0.6 7c76_A hetero TGFB1_HUMAN compound NAG otherpoly 
NEDTKSACGLMQRVHI
 REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 10" TOPO_DOM /note="Lumenal" N->I:(1.0 %):LB/B - dbSNP:rs5743316
307YSe 31.7 7c76_A hetero Q30BZ2_PHYSO FLIC_SALDU LY96_HUMAN E0U497_BACPZ TGFB1_HUMAN CIF2_ARATH Q16J57_AEDAE CADH1_HUMAN nucleotide compound RX8 MBL UPT M4D C09 D87 HB2 M0A IDQ CU8 DY3 U57 QLH I6A JRI YHG D80 XG1 NAG 7VF 7VL I5N metal ZN otherpoly homo 
HGNLSFQAREIYDKVPMTW
 REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 11" TOPO_DOM /note="Lumenal" Y->D:(3.0 %):LB/B - dbSNP:rs5743317
412LEb 1.7 7c76_A hetero LY86_MOUSE otherpoly 
LIVFAPRYEGKMNQSTW
 REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 15" TOPO_DOM /note="Lumenal" L->F:(4.0 %):LB/B - dbSNP:rs3775291
732FHe 86.6 8ar1_A 
FYLCMIKAH
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" F->L:(14.0 %):LB/B - dbSNP:rs9885865
737S e 51.6 8ar1_A 
TSCAMRGILKQYDENPV
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" S->T:(20.0 %):LB/B - dbSNP:rs5743318
867RHb 0.6 7nuw_A 
RLYADEFGIKNPQSTV
 DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" R->Q:(1.0 %):LB/B - dbSNP:rs1997689

Site Table for OMIM:US [2 variants]

2 sites 134,870
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
134S e 41.4 7c76_A hetero UNC5D_RAT F1LW30_RAT compound NAG metal CL otherpoly homo precipitant 
SKNRQALPTEGHCDFMVIY
 REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" REPEAT /note="LRR 4" TOPO_DOM /note="Lumenal" S->P:(5.0 %):US -
870MHb 5.7 3j0a_A 
LIYFMV
 DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" DOMAIN /note="TIR" TOPO_DOM /note="Cytoplasmic" M->V:(1.0 %):US -