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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2684896 1041 79 Q9NR97(TLR8_HUMAN) RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor;
QUERYSEQ 
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTE
LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH
IRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKT
INKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All 301078 Immunodeficiency 98 with autoinflammation, X-linked (IMD98) LB/B (likely benign or benign)
Number of sites 1041 3 2
Buired or ExposedBuried 49.5 (%) [385] 0.0 (%) [0] 0.0 (%) [0]
Exposed 50.5 (%) [393] 100.0 (%) [3] 100.0 (%) [1]
Ave relacc 26.7 % 56.0 % 48.2 %
SD relacc 26.21 % 28.88 % 0.00 %
Contact Molhetero 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
nucleotide 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
compound 14.9 (%) [155] 66.7 (%) [2] 0.0 (%) [0]
metal 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
otherpoly 4.0 (%) [42] 0.0 (%) [0] 0.0 (%) [0]
homo 10.8 (%) [112] 100.0 (%) [3] 0.0 (%) [0]
precipitant 6.1 (%) [64] 0.0 (%) [0] 50.0 (%) [1]
Number of variants 6 4 2
N_Freq(AAvariant)==0 % 0.0 % [0] 50.0 % [1]
N_Freq(AAvariant)>0 % 100.0 % [4] 50.0 % [1]
Ave Freq(AAvariant) 3.2 % 3.5 %
SD Freq(AAvariant) 1.64 % 3.50 %

Site Table for OMIM:301078 Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [4 variants]

3 sites 432,494,572
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
432P e 20.9 4qbz_A homo 
GPSAEVTCDFHKLNQRYIW
 REPEAT /note="LRR 12" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 12" TOPO_DOM /note="Extracellular" P->L:(2.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078]
494F e 55.5 4qbz_A compound CU8 7VF 7VC 7VL DY3 QSM QLH GD0 I6A I5N I5B RQY YHG O0W JRI homo 
STFGLREKVAINHPQDMY
 REPEAT /note="LRR 13" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 13" TOPO_DOM /note="Extracellular" F->L:(6.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078]
572GTe 91.7 4qbz_A compound RX8 UPT M4D MBL U57 C09 L07 D80 XG1 URI HB2 M8D M0A IDQ homo 
GAESKRNPCQTVDFHILMY
 REPEAT /note="LRR 16" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 16" TOPO_DOM /note="Extracellular" G->D:(2.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) dbSNP:rs1385657 [MIM:301078];G->V:(3.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078]

Site Table for OMIM:LB/B [2 variants]

2 sites 10,715
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
10M---- 
LITQWMS
 SIGNAL SIGNAL DISORDER predicted by DISOPRED M->V:(0.0 %):LB/B - dbSNP:rs5744077
715R e 48.2 4qbz_A precipitant 
RKLQDEITFMSAGHVYNP
 REPEAT /note="LRR 22" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 22" TOPO_DOM /note="Extracellular" R->Q:(7.0 %):LB/B - dbSNP:rs5744082