Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2684896 | 1041 | 79 | Q9NR97(TLR8_HUMAN) | RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor; |
QUERYSEQ |
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTE LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH IRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKT INKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY |
All | 301078 Immunodeficiency 98 with autoinflammation, X-linked (IMD98) | LB/B (likely benign or benign) | ||
Number of sites | 1041 | 3 | 2 | |
Buired or Exposed | Buried | 49.5 (%) [385] | 0.0 (%) [0] | 0.0 (%) [0] |
Exposed | 50.5 (%) [393] | 100.0 (%) [3] | 100.0 (%) [1] | |
Ave relacc | 26.7 % | 56.0 % | 48.2 % | |
SD relacc | 26.21 % | 28.88 % | 0.00 % | |
Contact Mol | hetero | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 14.9 (%) [155] | 66.7 (%) [2] | 0.0 (%) [0] | |
metal | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 4.0 (%) [42] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 10.8 (%) [112] | 100.0 (%) [3] | 0.0 (%) [0] | |
precipitant | 6.1 (%) [64] | 0.0 (%) [0] | 50.0 (%) [1] | |
Number of variants | 6 | 4 | 2 | |
N_Freq(AAvariant)==0 % | 0.0 % [0] | 50.0 % [1] | ||
N_Freq(AAvariant)>0 % | 100.0 % [4] | 50.0 % [1] | ||
Ave Freq(AAvariant) | 3.2 % | 3.5 % | ||
SD Freq(AAvariant) | 1.64 % | 3.50 % |
3 sites | 432,494,572 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
432 | P | e | 20.9 | 4qbz_A | homo | GPSAEVTCDFHKLNQRYIW |
REPEAT /note="LRR 12" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 12" TOPO_DOM /note="Extracellular" | P->L:(2.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078] | |
494 | F | e | 55.5 | 4qbz_A | compound CU8 7VF 7VC 7VL DY3 QSM QLH GD0 I6A I5N I5B RQY YHG O0W JRI homo | STFGLREKVAINHPQDMY |
REPEAT /note="LRR 13" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 13" TOPO_DOM /note="Extracellular" | F->L:(6.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078] | |
572 | G | T | e | 91.7 | 4qbz_A | compound RX8 UPT M4D MBL U57 C09 L07 D80 XG1 URI HB2 M8D M0A IDQ homo | GAESKRNPCQTVDFHILMY |
REPEAT /note="LRR 16" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 16" TOPO_DOM /note="Extracellular" | G->D:(2.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) dbSNP:rs1385657 [MIM:301078];G->V:(3.0 %):LP/P Immunodeficiency 98 with autoinflammation, X-linked (IMD98) [MIM:301078] |
2 sites | 10,715 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
10 | M | - | - | - | - | LITQWMS |
SIGNAL SIGNAL DISORDER predicted by DISOPRED | M->V:(0.0 %):LB/B - dbSNP:rs5744077 | |
715 | R | e | 48.2 | 4qbz_A | precipitant | RKLQDEITFMSAGHVYNP |
REPEAT /note="LRR 22" TOPO_DOM /note="Extracellular" REPEAT /note="LRR 22" TOPO_DOM /note="Extracellular" | R->Q:(7.0 %):LB/B - dbSNP:rs5744082 |