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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2634797 165 1500 P05161(ISG15_HUMAN) RecName: Full=Ubiquitin-like protein ISG15;AltName: Full=Interferon-induced 15 kDa protein;AltName: Full=Interferon-induced 17 kDa protein; Short=IP17;AltName: Full=Ubiquitin cross-reactive protein; Short=hUCRP;Flags: Precursor;
QUERYSEQ 
MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFM
NLRLRGGGTEPGGRS
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 165 1
Buired or ExposedBuried 32.9 (%) [52] 0.0 (%) [0]
Exposed 67.1 (%) [106] 100.0 (%) [1]
Ave relacc 37.6 % 40.6 %
SD relacc 29.27 % 0.00 %
Contact Molhetero 80.0 (%) [132] 100.0 (%) [1]
nucleotide 9.7 (%) [16] 0.0 (%) [0]
compound 32.7 (%) [54] 0.0 (%) [0]
metal 41.8 (%) [69] 100.0 (%) [1]
otherpoly 21.8 (%) [36] 0.0 (%) [0]
homo 55.2 (%) [91] 100.0 (%) [1]
precipitant 63.0 (%) [104] 100.0 (%) [1]
Number of variants 1 1
N_Freq(AAvariant)==0 % 0.0 % [0]
N_Freq(AAvariant)>0 % 100.0 % [1]
Ave Freq(AAvariant) 5.0 %
SD Freq(AAvariant) 0.00 %

Site Table for OMIM:LB/B [1 variants]

1 sites 83
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
83SEe 40.6 7rbs_B hetero UBP7_HUMAN F105B_HUMAN UBP30_HUMAN UBP14_HUMAN E7FEV5_DANRE NEMO_MOUSE UBP2_HUMAN UBP21_HUMAN UBP8_YEAST HOIL1_MOUSE UBP46_HUMAN TNIP1_MOUSE UBP1_HUMAN TNIP1_HUMAN NEMO_HUMAN Q5ZTB4_LEGPH UBP34_HUMAN UBP5_HUMAN RNF31_HUMAN UBP6_YEAST UBP18_MOUSE TNIP2_HUMAN UBP35_HUMAN OPTN_MOUSE Q5ZSI8_LEGPH A0A6A5PXS0_YEASX UBP36_HUMAN ADRM1_HUMAN Q22240_CAEEL Q5ZSJ1_LEGPH NOD1_HUMAN A0A0R4ILB8_DANRE UBP12_HUMAN OTUL_HUMAN UBB_HUMAN E0W1I1_PEDHC B9G207_ORYSJ PRKN_HUMAN C4QY61_KOMPG Q6IB93_HUMAN metal ZN CD CL NA homo precipitant 
QSFMN
 MUTAGEN /note="S->A: Does not affect ISG15 signaling, interaction with ITGAL or activation of SRC family tyrosine kinases." DOMAIN /note="Ubiquitin-like 2" MUTAGEN /note="S->A: Does not affect ISG15 signaling, interaction with ITGAL or activation of SRC family tyrosine kinases." DOMAIN /note="Ubiquitin-like 2" S->N:(5.0 %):LB/B - dbSNP:rs1921