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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2622207 358 91 P13747(HLAE_HUMAN) RecName: Full=HLA class I histocompatibility antigen, alpha chain E;AltName: Full=MHC class I antigen E;Contains: RecName: Full=Soluble HLA class I histocompatibility antigen, alpha chain E; Short=sHLA-E ;Flags: Precursor;
QUERYSEQ 
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNED
LRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 358 3
Buired or ExposedBuried 37.0 (%) [102] 0.0 (%) [0]
Exposed 63.0 (%) [174] 100.0 (%) [3]
Ave relacc 32.9 % 30.7 %
SD relacc 26.03 % 7.25 %
Contact Molhetero 36.0 (%) [129] 66.7 (%) [2]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 0.0 (%) [0] 0.0 (%) [0]
metal 2.8 (%) [10] 0.0 (%) [0]
otherpoly 0.0 (%) [0] 0.0 (%) [0]
homo 13.1 (%) [47] 0.0 (%) [0]
precipitant 34.6 (%) [124] 66.7 (%) [2]
Number of variants 3 3
N_Freq(AAvariant)==0 % 33.3 % [1]
N_Freq(AAvariant)>0 % 66.7 % [2]
Ave Freq(AAvariant) 0.7 %
SD Freq(AAvariant) 0.47 %

Site Table for OMIM:LB/B [3 variants]

3 sites 98,128,178
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
98NHe 31.5 7p4b_C hetero HLAG_HUMAN INHA_MYCTU RASN_HUMAN PPSB_MYCTU ESXH_MYCTU Q0QI92_HCMV 1C07_HUMAN D9J353_9INFA B6S6I4_9HIV1 precipitant 
DENASGTYQMIKLPRV
 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" REGION /note="Alpha-1" TOPO_DOM /note="Extracellular" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" REGION /note="Alpha-1" TOPO_DOM /note="Extracellular" N->K:(1.0 %):LB/B - dbSNP:rs1059510
128GSe 21.4 7p4b_C 
GNTQSEW
 REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" G->R:(0.0 %):LB/B - dbSNP:rs1264457
178RHe 39.1 7p4b_C hetero TVA4_HUMAN A0A075B6U7_HUMAN TRAR1_HUMAN TCA_HUMAN NKG2A_HUMAN TVB14_HUMAN TJB23_HUMAN TRBC2_HUMAN precipitant 
RKIQAEHFLTVDGNY
 REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" R->G:(1.0 %):LB/B - dbSNP:rs4156231