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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2622207 358 1500 P13747(HLAE_HUMAN) RecName: Full=HLA class I histocompatibility antigen, alpha chain E;AltName: Full=MHC class I antigen E;Contains: RecName: Full=Soluble HLA class I histocompatibility antigen, alpha chain E; Short=sHLA-E ;Flags: Precursor;
QUERYSEQ 
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNED
LRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 358 3
Buired or ExposedBuried 36.6 (%) [102] 0.0 (%) [0]
Exposed 63.4 (%) [177] 100.0 (%) [3]
Ave relacc 33.7 % 30.7 %
SD relacc 26.96 % 7.25 %
Contact Molhetero 58.9 (%) [211] 100.0 (%) [3]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 24.3 (%) [87] 100.0 (%) [3]
metal 56.4 (%) [202] 100.0 (%) [3]
otherpoly 3.9 (%) [14] 0.0 (%) [0]
homo 34.1 (%) [122] 66.7 (%) [2]
precipitant 73.7 (%) [264] 100.0 (%) [3]
Number of variants 3 3
N_Freq(AAvariant)==0 % 33.3 % [1]
N_Freq(AAvariant)>0 % 66.7 % [2]
Ave Freq(AAvariant) 0.7 %
SD Freq(AAvariant) 0.47 %

Site Table for OMIM:LB/B [3 variants]

3 sites 98,128,178
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
98NHe 31.5 7p4b_C hetero SPIKE_SARS2 MAR1_HUMAN RTA_EBVG RASN_HUMAN INS_HUMAN P53_HUMAN CTG1B_HUMAN NCAP_SARS2 VIPR1_HUMAN Q9YYU8_9HIV1 NEF_HV1ND TAT_HTL1C HLAG_HUMAN Q9YYU3_9HIV1 EBNA1_EBVB9 INHA_MYCTU KMT2A_HUMAN POL_HV1Z2 PP65_HCMVA EBNA6_EBV BZLF1_EBVB9 Q5QGG3_SIVCZ EBNA3_EBVG IGKC_HUMAN Q90VG9_9HIV1 HAUS3_HUMAN PMEL_HUMAN POL_HV1B1 Q95HB9_HUMAN POLG_HCVJ1 DDX3X_HUMAN IDHP_HUMAN MAGA4_HUMAN PME17_HUMAN LMP2_EBV WT1_HUMAN Q1WDM0_9INFA Q6SW59_HCMV Q9YJW5_HBV BZLF1_EBVG X2G898_9HEPC NEF_SIVS4 HHAT_HUMAN PK3CA_HUMAN IBPL1_HUMAN PPSB_MYCTU ESXH_MYCTU MAGAA_HUMAN EBN3_EBV BZLF1_EBV TERT_HUMAN H2AX_HUMAN KPCD2_HUMAN LSP1_HUMAN PPGB_HUMAN Q692E0_CVHSA POL_SIVSP Q9WH73_SIVCZ Q5QGH9_SIVCZ HA1L_MOUSE Q9WPU2_9HIV1 TAX_HTL1F Q9YXL6_9INFA Q70A36_9HIV1 E9P5U1_9INFA Q80817_9DELA W0GUW4_9HIV1 R1AB_SARS2 EBN6_EBV ATP6_RAT ENV_HV1B8 M1_IAPUE POL_HV1MA VIPR_HUMAN ERBB2_HUMAN NEF_HV1Z6 Q9TQB0_HUMAN TISD_HUMAN MAG1_HUMAN NCAP_CVHSA O11822_9HIV1 CRTC_HUMAN EBN1_EBV CO024_HUMAN ENV_HV1MA Q0QI92_HCMV POF1B_HUMAN 1C07_HUMAN Q9YYH6_9HIV1 VME1_CVHSA EB2_EBVG Q9DIT6_9HEPC Q9YKD7_9PARA Q9WDF0_9INFA LMP2_EBVB9 Q89490_SIVCZ Q9YXL3_9INFA Q9YXW1_9HIV1 Q9YNZ1_9HIV1 Q9QAC5_HBV R4WL38_9HIV1 A14_VACCW AMPD2_HUMAN EBNA1_EBVG EBNA1_EBVA8 M1_I34A1 C1KG39_CANFA W8FN10_9FLAV O11793_9HIV1 O11803_9HIV1 GAG_FIVPE Q9WGX1_9HIV1 RETR2_HUMAN SYNEM_HUMAN A0A0U1RRH7_HUMAN CTNB1_HUMAN EBNA3_EBVB9 SPIKE_CVCAK POL_HV1BR NCAP_CVH22 PHX2B_HUMAN DOT1L_HUMAN NCAP_INBSI M1_INBAC I27RA_HUMAN NCAP_I46A1 NCAP_FIPV NCAP_I72A4 POL_HV1U4 IMA2_HUMAN CORA_HBVIL RL19_HUMANX MAGA3_HUMAN SNX5_HUMAN UB2E1_HUMAN Q8B2U6_9INFA Q70A02_9HIV1 Q701N7_9INFA CP2CI_HUMAN Q1M075_9HIV1 Q1KW74_9HIV1 Q4MYJ2_THEPA MYPR_HUMAN Q70XD7_9HIV1 N4BP2_HUMAN MAGA1_HUMAN GLR_HUMAN HMHA1_HUMAN HNRPC_HUMAN MTAP_HUMAN CAC1D_HUMAN FETA_HUMAN SO2A1_HUMAN A7UMS0_EBVG HEMA_RINDR Q9YV12_9HIV1 F5HB26_HCMV Q9Q5D4_9HIV1 Q9WPV9_9HIV1 Q9YXY3_9HIV1 O75767_HUMAN ENV_HV1LW R4P6M5_9INFA R4X2K3_9INFA D9J353_9INFA PP65_HCMVT Q9YRL3_HCMV Q9YRL8_HCMV VIE1_HCMVT T2D0U8_9HIV1 TITIN_HUMAN E9PM67_HUMAN W8EGN4_9HIV1 B6D4Y8_HUMAN I6YDJ5_PRRSV CCND2_HUMAN NCAP_SARS NCAP_INBAC B6S6I4_9HIV1 NS1_INBSJ RDRP_I97A1 M1_INBYA A0A125R5A5_9ALPC NCAP_I57A5 MAGA8_HUMAN RASK_HUMAN M1_I78A8 RDRP_I78A8 compound ARG MET metal NA CL homo precipitant 
DENASGTYQMIKLPRV
 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" REGION /note="Alpha-1" TOPO_DOM /note="Extracellular" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" REGION /note="Alpha-1" TOPO_DOM /note="Extracellular" N->K:(1.0 %):LB/B - dbSNP:rs1059510
128GSe 21.4 7p4b_C hetero US02_HCMVA compound TAM metal NA precipitant 
GNTQSEW
 REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" G->R:(0.0 %):LB/B - dbSNP:rs1264457
178RHe 39.1 7p4b_C hetero TCA_HUMAN K7N5M3_HUMAN A0A0B4J279_HUMAN A0A075B6T6_HUMAN TVA4_HUMAN A0A075B6U7_HUMAN TRAR1_HUMAN NKG2A_HUMAN H2RG00_PANTR K7N5M9_HUMAN TVA22_HUMAN TVB14_HUMAN TJB23_HUMAN TRBC2_HUMAN Q9WU32_MOUSE compound TAM metal CL homo precipitant 
RKIQAEHFLTVDGNY
 REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" REGION /note="Alpha-2" TOPO_DOM /note="Extracellular" R->G:(1.0 %):LB/B - dbSNP:rs4156231