Summary for the 378-th Site(K)
PID QueryLength FocusSite TITLE
20585 425 378 K RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3;
UniProt Information
AC/IDAC:P84022 ID:SMAD3_HUMAN
Feature Table for 378-th site MOD_RES: /note="N6-acetyllysine"
MUTAGEN: /note="K->Q: Increased transcriptional activity. No further increase in transcriptional activity with EP300."
MUTAGEN: /note="K->R: Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409."
DOMAIN: /note="MH2"
CHAIN: /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
K:100%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1mk2 (coil) e (exposed) 43.9
3D Complex Information
Predicted Bind Molecules
hetero:2 homo:22 precipitant:8
Templates for 3D complexes
hetero [47815:SMAD3_HUMAN ] 1u7f_B_1_A_1 1u7v_C_1_A_1 homo [50456:SMAD1_HUMAN ] 1khu_A_1_B_1 1khu_C_1_A_1 5zok_A_1_A_2 5zok_A_2_A_4 5zok_A_4_A_1 5zok_C_1_C_5 5zok_C_3_C_1 5zok_C_5_C_3 [47815:SMAD2_HUMAN ] 1khx_A_1_A_2 1khx_A_2_A_3 1khx_A_3_A_1 1u7f_A_1_C_1 1u7v_A_1_B_1 6m64_E_1_A_1 6zvq_A_1_A_2 6zvq_A_2_A_3 6zvq_A_3_A_1 [46223:MAD_DROME ] 3gmj_A_1_A_3 3gmj_A_2_A_1 3gmj_A_3_A_2 3gmj_B_1_C_1 3gmj_D_1_B_1 precipitant [SO4 ] 1dd1_A_1_E_1 1dd1_A_2_E_2 1dd1_B_1_F_1 1dd1_B_2_F_2 1dd1_C_1_L_1 1dd1_C_2_L_2 7cd1_B_1_J_1 7cd1_C_1_M_1


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