Summary for the 287-th Site(R)
PID QueryLength FocusSite TITLE
20585 425 287 R RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3;
UniProt Information
AC/IDAC:P84022 ID:SMAD3_HUMAN
Feature Table for 287-th site VARIANT: /note="R -> W (in LDS3; dbSNP:rs387906850)" /id="VAR_065579"
HELIX:
REGION: /note="Sufficient for interaction with XPO4"
DOMAIN: /note="MH2"
CHAIN: /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856"
VARIANT for 287-th site R->W LP/P dbSNP:rs3879068 " Loeys-Dietz syndrome 3 (LDS3) " [MIM:613795]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
R:100%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1mk2 H (alpha-helix) b (buried) 10.3
3D Complex Information
Predicted Bind Molecules
hetero:4 homo:41 compound:3
Templates for 3D complexes
hetero [47815:SMAD3_HUMAN ] 1u7f_B_1_A_1 1u7v_C_1_A_1 [58293:SMAD4_HUMAN ] 1u7f_C_1_B_1 1u7v_B_1_C_1 homo [64871:SMAD4_HUMAN ] 1dd1_A_1_B_1 1dd1_A_2_B_2 [58293:SMAD4_HUMAN ] 1dd1_C_1_A_1 1dd1_C_2_A_2 1g88_C_1_A_1 [50456:SMAD1_HUMAN ] 1khu_A_1_B_1 1khu_C_1_A_1 1khu_D_1_D_3 1khu_D_2_D_1 1khu_D_3_D_2 5zok_A_1_A_2 5zok_A_2_A_4 5zok_A_4_A_1 5zok_C_1_C_5 5zok_C_3_C_1 5zok_C_5_C_3 [47815:SMAD2_HUMAN ] 1khx_A_1_A_2 1khx_A_2_A_3 1khx_A_3_A_1 1u7f_A_1_C_1 1u7v_A_1_B_1 5xod_A_1_A_2 5xod_A_2_A_3 5xod_A_3_A_1 5zoj_A_1_B_1 5zoj_B_1_C_1 6m64_A_1_C_1 6m64_C_1_E_1 6m64_E_1_A_1 6zvq_A_1_A_2 6zvq_A_2_A_3 6zvq_A_3_A_1 7co1_A_1_C_1 7co1_C_1_E_1 7co1_E_1_A_1 [46223:MAD_DROME ] 3gmj_A_1_A_3 3gmj_A_2_A_1 3gmj_A_3_A_2 3gmj_B_1_C_1 3gmj_C_1_D_1 3gmj_D_1_B_1 compound [TAR ] 6zvq_A_1_J_2 6zvq_A_2_J_3 6zvq_A_3_J_1


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