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| PID | QueryLength | FocusSite | TITLE |
| 20585 | 425 | 279 R | RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3; |
| AC/ID | AC:P84022 ID:SMAD3_HUMAN |
| Feature Table for 279-th site |
VARIANT: /note="R -> K (in LDS3; dbSNP:rs387906852)" /id="VAR_067048" REGION: /note="Sufficient for interaction with XPO4" DOMAIN: /note="MH2" CHAIN: /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856" |
| VARIANT for 279-th site |
R->K LP/P dbSNP:rs3879068 " Loeys-Dietz syndrome 3 (LDS3) " [MIM:613795] |
Percentages of Amino Acids in Homologous Proteins
 [show alignment]
|
R:92% K:8% |
| Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
 1mk2 |
(coil) | e (exposed) | 24.1 |
| Predicted Bind Molecules |
| hetero:2 homo:12 compound:3 precipitant:5 |
| Templates for 3D complexes |
|
hetero [58293:SMAD4_HUMAN
] 1u7f_C_1_B_1 1u7v_B_1_C_1
homo [64871:SMAD4_HUMAN
] 1dd1_A_1_B_1 1dd1_A_2_B_2 1dd1_B_1_C_1 1dd1_B_2_C_2 1g88_A_1_B_1 1g88_B_1_C_1 [58293:SMAD4_HUMAN
] 1dd1_C_1_A_1 1dd1_C_2_A_2 1g88_C_1_A_1 1ygs_A_1_A_3 1ygs_A_2_A_1 1ygs_A_3_A_2
compound [TAR ] 6zvq_A_1_J_2 6zvq_A_2_J_3 6zvq_A_3_J_1
precipitant [SO4 ] 1dd1_B_1_K_1 1dd1_B_2_K_2 [GOL ] 6zvq_A_1_F_1 6zvq_A_2_F_2 6zvq_A_3_F_3
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Summary for the 279-th Site(R)