Summary for the 79-th Site(L)
PID QueryLength FocusSite TITLE
18353 805 79 L RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 79-th site MUTAGEN: /note="L->T: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
TURN:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
Q:25% L:16% D:12% E:12% R:10% W:10% A:5% M:4% I:3% T:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 G (3/10-helix) e (exposed) 39.3
3D Complex Information
Predicted Bind Molecules
hetero:140 precipitant:2
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 2ajf_A_1_C_1 3d0g_B_1_D_1 3d0h_A_1_C_1 3d0h_B_1_D_1 3scl_B_1_D_1 7wsf_A_1_B_1 7wsg_A_1_B_1 [100563:SPIKE_CVHSA ] 6acg_D_1_C_1 6acj_D_1_C_1 6ack_D_1_C_1 [44643:SPIKE_SARS2 ] 6m0j_A_1_B_1 7ddo_A_1_B_1 7dmu_C_1_D_1 7efp_A_1_B_1 7efr_A_1_B_1 7ekc_A_1_B_1 7ekg_A_1_B_1 7fdg_A_1_B_1 7fdi_A_1_B_1 7fdk_A_1_B_1 7l0n_I_1_K_1 7l0n_J_1_L_1 7pki_A_1_B_1 7rpv_A_1_B_1 7rpv_C_1_D_1 7rpv_G_1_H_1 7sn0_A_1_C_1 7sy4_B_1_A_1 7sy6_B_1_A_1 7sy8_B_1_A_1 7v80_B_1_A_1 7vx4_A_1_B_1 7w8s_A_1_B_1 7wa1_A_1_B_1 7wse_A_1_B_1 7wsh_A_1_B_1 8df5_F_1_L_1 8dln_B_1_A_1 8jje_A_1_B_1 8ka8_A_1_B_1 8t25_A_1_B_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 7ufk_A_1_C_1 7ufk_B_1_D_1 7ufl_A_1_C_1 8spi_B_1_D_1 [100295:SPIKE_SARS2 ] 7a94_D_1_A_1 7a97_E_1_B_1 7a98_B_1_A_1 7a98_C_1_E_1 7df4_A_1_C_1 7dx5_D_1_A_1 7dx6_D_1_A_1 7dx7_D_1_A_1 7dx8_D_1_A_1 7dx8_E_1_C_1 7dx9_D_1_A_1 7dx9_E_1_C_1 7kj2_D_1_B_1 7kj3_D_1_B_1 7kj3_E_1_A_1 7kj4_D_1_B_1 7kj4_E_1_C_1 7kj4_F_1_A_1 7kmz_E_1_D_1 7knh_C_1_B_1 7knh_E_1_D_1 7sy5_F_1_C_1 7t9k_D_1_A_1 7t9k_E_1_B_1 7v7z_D_1_A_1 7v7z_F_1_C_1 7v88_E_1_C_1 7vxd_C_1_A_1 7vxf_B_1_A_1 7vxk_B_1_A_1 7vxm_B_1_A_1 7w98_C_1_D_1 7wk4_A_1_B_1 7wk5_A_1_B_1 7wpa_D_1_A_1 7ws8_D_1_A_1 7ws9_D_1_A_1 7wvp_A_1_B_1 7xch_D_1_A_1 7xch_E_1_C_1 7xo5_D_1_A_1 7xo7_D_1_C_1 7xo7_E_1_A_1 7xo8_D_1_A_1 7xo8_E_1_C_1 7xo8_F_1_B_1 7xoa_D_1_A_1 7xob_C_1_A_1 7xob_E_1_D_1 7ya0_D_1_A_1 7ya0_F_1_C_1 7yeg_J_1_B_1 7yr2_A_1_B_1 8dlp_F_1_C_1 8dm5_D_1_A_1 8dm5_E_1_B_1 8i9b_D_1_C_1 8i9b_E_1_A_1 8i9b_F_1_B_1 8vko_D_1_A_1 8vko_E_1_B_1 8vko_F_1_C_1 8wgv_E_1_B_1 8wgv_F_1_C_1 8wrm_D_1_B_1 [55210:A0A6B9WHD3_SARS ] 7p8j_A_1_B_1 [45054:SPIKE_SARS2 ] 7tn0_E_1_I_1 7tn0_F_1_L_1 7wbl_A_1_B_1 7wgc_A_1_B_1 7whh_A_1_B_1 7wsa_B_1_A_1 7xb0_A_1_B_1 7xb1_A_1_B_1 7xci_A_1_B_1 7xcp_A_1_B_1 7xo6_A_1_B_1 7xo9_B_1_A_1 7xoc_A_1_B_1 7yr4_A_1_B_1 7yv8_A_1_B_1 8aqu_A_1_B_1 8aqv_A_1_B_1 8dm6_B_1_A_1 8kc2_A_1_B_1 8wrl_A_1_B_1 [86498 ] 7v61_B_1_C_1 7v61_F_1_G_1 [47457:A0A6G6A2Q2_9BETC ] 7vib_A_1_B_1 7vib_C_1_D_1 [53268 ] 7xbg_A_1_B_1 [61398:SPIKE_SARS2 ] 8fxb_C_1_D_1 [100974:A0A7D6P0R3_9BETC ] 8hxk_A_1_B_1 [63051 ] 8u0t_A_1_B_1 precipitant [EDO ] 8qfx_A_1_Z_1 [GOL ] 8tos_A_1_J_1


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