Summary for the 69-th Site(W)
PID QueryLength FocusSite TITLE
18353 805 69 W RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 69-th site MUTAGEN: /note="W->V: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
L:27% W:23% V:15% N:14% R:7% I:7% M:4%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 H (alpha-helix) b (buried) 16.3
3D Complex Information
Predicted Bind Molecules
hetero:12 otherpoly:4 compound:3 precipitant:6
Templates for 3D complexes
hetero [5922:BNP_GLOBL ] 4apj_A_1_B_1 6qs1_A_1_C_1 [9413 ] 8b9p_A_1_C_1 8b9p_B_1_D_1 [10410 ] 8bn1_B_1_C_1 [9348 ] 8byj_B_1_C_1 [9678 ] 8toq_A_1_B_1 [9677 ] 8tor_A_1_B_1 8tot_A_1_C_1 8tot_B_1_D_1 8tou_A_1_B_1 [10324 ] 8tos_A_1_B_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7wbp_A_1_C_1 7xcp_A_1_E_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 7xb1_A_1_D_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 8h5c_A_1_D_1 compound [3ES ] 2xy9_A_1_J_1 [LFI ] 8b9p_A_1_E_1 8b9p_B_1_F_1 precipitant [EDO ] 6f9u_A_1_L_1 6zpq_A_1_U_1 6zpt_C_1_X_1 [BO3 ] 7q27_A_1_O_1 [GOL ] 8asy_A_1_O_1 [PGE ] 8qfx_B_1_SA_1


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