Summary for the 393-rd Site(R)
PID QueryLength FocusSite TITLE
18353 805 393 R RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 393-th site MUTAGEN: /note="R->A: Slightly inhibits interaction with SARS-CoV spike glycoprotein."
MUTAGEN: /note="R->K: Increases very slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
R:93% Q:7%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 (coil) e (exposed) 24.1
3D Complex Information
Predicted Bind Molecules
hetero:118 otherpoly:2 compound:4 metal:2 precipitant:18
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 3d0h_A_1_C_1 3d0h_B_1_D_1 3d0i_A_1_C_1 8woz_A_1_B_1 [34874:SPIKE_CVHNL ] 3kbh_A_1_B_1 3kbh_C_1_D_1 3kbh_E_1_F_1 3kbh_G_1_H_1 [100563:SPIKE_CVHSA :D9IEJ2_BPT4 ] 6cs2_D_1_B_1 [44643:SPIKE_SARS2 ] 6m0j_A_1_B_1 7a91_A_1_B_1 7c8d_A_1_B_1 7c8j_A_1_B_1 7dmu_A_1_B_1 7dmu_C_1_D_1 7dqa_A_1_B_1 7dx4_A_1_B_1 7e3j_A_1_B_1 7efp_A_1_B_1 7efr_A_1_B_1 7ekc_A_1_B_1 7eke_A_1_B_1 7ekh_A_1_B_1 7f5r_A_1_B_1 7f5r_C_1_D_1 7f5r_E_1_F_1 7fc5_B_1_A_1 7fdg_A_1_B_1 7fdi_A_1_B_1 7l0n_I_1_K_1 7l0n_J_1_L_1 7lo4_A_1_B_1 7pki_A_1_B_1 7rpv_E_1_F_1 7rpv_G_1_H_1 7sn0_A_1_C_1 7sn0_B_1_D_1 7sxy_B_1_A_1 7sy0_B_1_A_1 7sy2_B_1_A_1 7sy8_B_1_A_1 7tew_B_1_A_1 7tez_B_1_A_1 7vx4_A_1_B_1 7vx5_A_1_B_1 7w9i_A_1_B_1 7wa1_A_1_B_1 7wbq_A_1_B_1 7wbq_C_1_D_1 7wnm_A_1_B_1 7wse_A_1_B_1 7wsh_A_1_B_1 7xa7_C_1_D_1 7xa7_E_1_F_1 7xa7_G_1_H_1 8dlk_B_1_A_1 8dln_B_1_A_1 8dlq_B_1_A_1 8dlv_B_1_A_1 8dv1_B_1_A_1 8dv2_B_1_A_1 8t25_A_1_B_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 [95898:SPIKE_SARS2 ] 7a92_A_1_B_1 [100295:SPIKE_SARS2 ] 7a95_D_1_A_1 7a97_D_1_A_1 7df4_A_1_C_1 7kj2_D_1_B_1 7kj4_D_1_B_1 7sxx_D_1_B_1 7sxz_D_1_B_1 7sy1_D_1_B_1 7sy3_D_1_B_1 7sy7_D_1_B_1 7tex_D_1_B_1 7tf0_D_1_B_1 7v81_E_1_C_1 7v82_F_1_C_1 7vx9_D_1_C_1 7vxa_B_1_A_1 7vxb_B_1_A_1 7vxc_B_1_A_1 7vxd_C_1_A_1 7vxf_B_1_A_1 7vxk_B_1_A_1 7vxm_B_1_A_1 7w99_C_1_D_1 7w9c_C_1_D_1 8dlj_D_1_B_1 8dlm_D_1_B_1 8dlp_D_1_A_1 8dlu_D_1_A_1 8dlu_E_1_B_1 [47457:A0A6G6A1M4_9BETC ] 7ddp_A_1_B_1 7vib_A_1_B_1 7vib_C_1_D_1 [33454:SPIKE_CVHNL ] 7fc3_B_1_A_1 [53268 ] 7xbf_A_1_B_1 7xbf_C_1_D_1 7xbg_A_1_B_1 7xbg_C_1_D_1 7xbh_B_1_A_1 [9413 ] 8b9p_A_1_C_1 8b9p_B_1_D_1 [9348 ] 8bfw_A_1_B_1 8bfw_C_1_D_1 8byj_A_1_D_1 8byj_B_1_C_1 [10410 ] 8bn1_A_1_D_1 8bn1_B_1_C_1 [100974:A0A7D6P0R3_9BETC ] 8hxk_A_1_B_1 [9678 ] 8toq_A_1_B_1 [9677 ] 8tor_A_1_B_1 8tot_A_1_C_1 8tot_B_1_D_1 8tou_A_1_B_1 [10324 ] 8tos_A_1_B_1 [63051 ] 8u0t_A_1_B_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 6f9t_A_1_C_1 [beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7sn0_B_1_O_1 compound [NAG ] 3bkk_A_1_D_1 3bkl_A_1_D_1 [FT8 ] 6h5w_A_1_H_1 [BCN ] 6tt3_A_1_V_1 metal [CL ] 8df5_E_1_TA_1 8df5_F_1_IB_1 precipitant [EPE ] 2xy9_A_1_H_1 [P6G ] 4ufb_C_1_OA_1 4ufb_D_1_VA_1 5amb_A_1_Q_1 [EDO ] 6tt3_B_1_FA_1 7lo4_A_1_G_1 7ufl_A_1_M_1 8qfx_A_1_BA_1 [1PE ] 7q25_A_1_J_1 7q26_A_1_N_1 8qfx_C_1_HB_1 [PEG ] 7z6z_A_1_I_1 8qfx_B_1_PA_1 8qhl_C_1_CA_1 [GOL ] 8asy_A_1_N_1 [PGE ] 8qfx_A_1_S_1 8qfx_B_1_SA_1 [PG4 ] 8qfx_D_1_XB_1


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