Summary for the 37-th Site(E)
PID QueryLength FocusSite TITLE
18353 805 37 E RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 37-th site MUTAGEN: /note="E->A: No effect on interaction with SARS-CoV spike glycoprotein."
REGION: /note="Interaction with SARS-CoV spike glycoprotein"
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
E:31% Q:23% I:14% A:12% R:11% G:7% K:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 H (alpha-helix) b (buried) 12.1
3D Complex Information
Predicted Bind Molecules
hetero:175 otherpoly:8 compound:4 precipitant:4
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 2ajf_A_1_C_1 2ajf_B_1_D_1 3d0h_A_1_C_1 3d0h_B_1_D_1 3d0i_A_1_C_1 3sci_A_1_C_1 3sci_B_1_D_1 3scj_A_1_C_1 3scj_B_1_D_1 3scl_A_1_C_1 7fc6_A_1_B_1 7wsf_A_1_B_1 7wsg_A_1_B_1 [34874:SPIKE_CVHNL ] 3kbh_A_1_B_1 3kbh_C_1_D_1 3kbh_E_1_F_1 3kbh_G_1_H_1 [44643:SPIKE_SARS2 ] 6lzg_A_1_B_1 6m0j_A_1_B_1 6m17_B_1_C_1 6m17_E_1_F_1 7a91_A_1_B_1 7c8j_A_1_B_1 7ddo_A_1_B_1 7dhx_A_1_B_1 7dmu_A_1_B_1 7dmu_C_1_D_1 7dqa_A_1_B_1 7e3j_A_1_B_1 7efp_A_1_B_1 7efr_A_1_B_1 7ekc_A_1_B_1 7eke_A_1_B_1 7ekf_A_1_B_1 7ekg_A_1_B_1 7f5r_A_1_B_1 7f5r_C_1_D_1 7f5r_E_1_F_1 7fc5_B_1_A_1 7fdh_A_1_B_1 7fdi_A_1_B_1 7l0n_I_1_K_1 7l0n_J_1_L_1 7l7f_A_1_B_1 7l7f_C_1_D_1 7lo4_A_1_B_1 7mjn_B_1_A_1 7nxc_A_1_B_1 7p19_A_1_B_1 7pki_A_1_B_1 7r12_A_1_B_1 7rpv_A_1_B_1 7rpv_C_1_D_1 7rpv_E_1_F_1 7rpv_G_1_H_1 7sn0_A_1_C_1 7sn0_B_1_D_1 7sxy_B_1_A_1 7sy0_B_1_A_1 7sy2_B_1_A_1 7sy4_B_1_A_1 7sy6_B_1_A_1 7sy8_B_1_A_1 7tew_B_1_A_1 7tez_B_1_A_1 7v87_B_1_A_1 7vx5_A_1_B_1 7w6u_A_1_B_1 7w8s_A_1_B_1 7w9i_A_1_B_1 7wa1_A_1_B_1 7wbq_A_1_B_1 7wbq_C_1_D_1 7wnm_A_1_B_1 7wse_A_1_B_1 7xa7_A_1_B_1 7xa7_C_1_D_1 7xa7_E_1_F_1 7xa7_G_1_H_1 7ydi_A_1_B_1 7zdq_A_1_B_1 8df5_E_1_K_1 8df5_F_1_L_1 8dlk_B_1_A_1 8dln_B_1_A_1 8dlq_B_1_A_1 8dlv_B_1_A_1 8dv1_B_1_A_1 8dv2_B_1_A_1 8hrk_A_1_B_1 8jje_A_1_B_1 8wlr_A_1_B_1 8wox_B_1_A_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 6vw1_B_1_D_1 [95898:SPIKE_SARS2 ] 7a92_A_1_B_1 [100295:SPIKE_SARS2 ] 7a96_D_1_A_1 7ct5_D_1_A_1 7ct5_E_1_B_1 7ct5_F_1_C_1 7dwx_B_1_E_1 7dwx_D_1_H_1 7fem_D_1_A_1 7kj2_D_1_B_1 7kj3_D_1_B_1 7kj4_D_1_B_1 7kmz_C_1_B_1 7kne_D_1_C_1 7knh_C_1_B_1 7mjm_D_1_A_1 7mjm_E_1_B_1 7r1a_B_1_E_1 7r1a_C_1_A_1 7r1a_D_1_F_1 7sxx_D_1_B_1 7sxz_D_1_B_1 7sy1_D_1_B_1 7sy3_D_1_B_1 7sy5_D_1_A_1 7sy5_E_1_B_1 7sy5_F_1_C_1 7sy7_D_1_B_1 7tex_D_1_B_1 7tf0_D_1_B_1 7v7z_F_1_C_1 7v85_E_1_B_1 7v86_D_1_A_1 7v86_F_1_C_1 7v88_E_1_C_1 7v8a_E_1_B_1 7v8a_F_1_C_1 7w98_C_1_D_1 7w99_C_1_D_1 7w9c_C_1_D_1 7xid_D_1_C_1 7xid_E_1_B_1 7xo4_D_1_A_1 7xo4_E_1_B_1 7xo5_D_1_A_1 8dlj_D_1_B_1 8dlm_D_1_B_1 8dlp_D_1_A_1 8dlp_E_1_B_1 8dlp_F_1_C_1 8dlu_D_1_A_1 8dlu_E_1_B_1 8t20_E_1_B_1 [48937:SPIKE_SARS2 ] 7bh9_A_1_B_1 [47457:A0A6G6A1M4_9BETC ] 7ddp_A_1_B_1 7vib_A_1_B_1 7vib_C_1_D_1 [33454:SPIKE_CVHNL ] 7fc3_B_1_A_1 [45054:SPIKE_SARS2 ] 7wbp_A_1_B_1 7wgc_A_1_B_1 7wpb_B_1_A_1 7xaz_C_1_D_1 7xb0_A_1_B_1 7xb1_A_1_B_1 7xby_A_1_B_1 7xcp_A_1_B_1 7xo6_A_1_B_1 7xwa_C_1_D_1 7y76_B_1_C_1 7y76_E_1_F_1 8aqu_A_1_B_1 8s9g_A_1_B_1 [53268 ] 7xbf_A_1_B_1 7xbf_C_1_D_1 7xbg_A_1_B_1 7xbg_C_1_D_1 7xbh_B_1_A_1 [9413 ] 8b9p_B_1_D_1 [10410 ] 8bn1_A_1_D_1 [100974:A0A7D6P0R3_9BETC ] 8hxk_A_1_B_1 [63051 ] 8u0t_A_1_B_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 2c6f_A_1_D_1 2c6f_B_1_F_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 6f9t_A_1_C_1 [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7q49_A_1_C_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7q4d_A_1_F_1 7q4d_B_1_L_1 7q4e_A_1_E_1 [beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7sn0_B_1_O_1 compound [NAG ] 2c6n_A_1_E_1 2c6n_B_1_L_1 3bkk_A_1_D_1 3bkl_A_1_D_1 precipitant [EPE ] 2xy9_A_1_H_1 [PEG ] 7pki_A_1_T_1 [EDO ] 8df5_E_1_OA_1 8df5_F_1_GB_1


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