Summary for the 35-th Site(E)
PID QueryLength FocusSite TITLE
18353 805 35 E RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 35-th site REGION: /note="Interaction with SARS-CoV spike glycoprotein"
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
E:55% T:24% S:9% Q:8% R:4%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 H (alpha-helix) e (exposed) 45.7
3D Complex Information
Predicted Bind Molecules
hetero:181 metal:1 precipitant:3
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 3d0h_A_1_C_1 3d0h_B_1_D_1 3d0i_A_1_C_1 3d0i_B_1_D_1 3scj_A_1_C_1 3scj_B_1_D_1 3sck_A_1_C_1 3sck_B_1_D_1 [44643:SPIKE_SARS2 ] 6lzg_A_1_B_1 6m0j_A_1_B_1 6m17_B_1_C_1 6m17_E_1_F_1 7c8j_A_1_B_1 7ddo_A_1_B_1 7dhx_A_1_B_1 7dmu_A_1_B_1 7dmu_C_1_D_1 7dqa_A_1_B_1 7dx4_A_1_B_1 7efr_A_1_B_1 7eke_A_1_B_1 7fc5_B_1_A_1 7fdh_A_1_B_1 7fdi_A_1_B_1 7fdk_A_1_B_1 7kmb_A_1_B_1 7l0n_I_1_K_1 7lo4_A_1_B_1 7mjn_B_1_A_1 7nxc_A_1_B_1 7p19_A_1_B_1 7p19_C_1_D_1 7pki_A_1_B_1 7r11_A_1_B_1 7rpv_A_1_B_1 7rpv_C_1_D_1 7rpv_E_1_F_1 7rpv_G_1_H_1 7sn0_A_1_C_1 7sn0_B_1_D_1 7sy4_B_1_A_1 7tew_B_1_A_1 7tez_B_1_A_1 7v87_B_1_A_1 7vx4_A_1_B_1 7vx5_A_1_B_1 7wa1_A_1_B_1 7wbq_A_1_B_1 7wse_A_1_B_1 7wsh_A_1_B_1 7xa7_A_1_B_1 7ydi_A_1_B_1 7zdq_A_1_B_1 8df5_E_1_K_1 8df5_F_1_L_1 8dv1_B_1_A_1 8dv2_B_1_A_1 8hg0_A_1_B_1 8jje_A_1_B_1 8ka8_A_1_B_1 8t23_A_1_B_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 6vw1_B_1_D_1 7ufk_A_1_C_1 7ufl_B_1_D_1 8sph_A_1_C_1 8sph_B_1_D_1 8spi_A_1_C_1 8spi_B_1_D_1 [100295:SPIKE_SARS2 ] 7a94_D_1_A_1 7df4_A_1_C_1 7dwx_B_1_E_1 7dwx_D_1_H_1 7edj_D_1_A_1 7edj_E_1_B_1 7kj2_D_1_B_1 7kj3_D_1_B_1 7kj4_D_1_B_1 7kj4_E_1_C_1 7kms_A_1_B_1 7kms_E_1_C_1 7kms_F_1_D_1 7kmz_E_1_D_1 7kne_D_1_C_1 7knh_E_1_D_1 7kni_D_1_A_1 7kni_E_1_B_1 7mjm_D_1_A_1 7mjm_E_1_B_1 7sxx_D_1_B_1 7sy3_D_1_B_1 7t9k_D_1_A_1 7t9k_E_1_B_1 7tex_D_1_B_1 7tf0_D_1_B_1 7wgb_E_1_B_1 7wk4_A_1_B_1 7wk5_A_1_B_1 7ws8_D_1_A_1 7ws9_D_1_A_1 7wvp_A_1_B_1 7xch_E_1_C_1 7xid_D_1_C_1 7xid_E_1_B_1 7xo8_D_1_A_1 7xo8_E_1_C_1 7xo8_F_1_B_1 7y1y_D_1_A_1 7y1y_E_1_B_1 7y1y_F_1_C_1 7y1z_D_1_B_1 7y1z_E_1_A_1 7y1z_F_1_C_1 7y20_D_1_A_1 7y20_E_1_C_1 7yeg_J_1_B_1 7yr2_A_1_B_1 8dm5_D_1_A_1 8dm5_E_1_B_1 8dm7_D_1_A_1 8dm7_E_1_B_1 8dm9_D_1_A_1 8hfx_D_1_A_1 8hfz_D_1_A_1 8ify_E_1_A_1 8jyn_D_1_A_1 8jyo_D_1_B_1 8jyo_E_1_A_1 8t20_D_1_C_1 8vko_D_1_A_1 8vko_E_1_B_1 8vko_F_1_C_1 8wgv_E_1_B_1 8wgv_F_1_C_1 [55210:A0A6B9WHD3_SARS ] 7drv_C_1_D_1 7p8j_A_1_B_1 7w6r_A_1_B_1 [45054:SPIKE_SARS2 ] 7t9l_B_1_A_1 7tn0_E_1_I_1 7tn0_F_1_L_1 7wbl_A_1_B_1 7wbp_A_1_B_1 7wgc_A_1_B_1 7whh_A_1_B_1 7wk6_B_1_A_1 7wpb_B_1_A_1 7wpc_C_1_A_1 7wsa_B_1_A_1 7xaz_A_1_B_1 7xaz_C_1_D_1 7xb0_A_1_B_1 7xb1_A_1_B_1 7xby_A_1_B_1 7xci_A_1_B_1 7xcp_A_1_B_1 7xo9_B_1_A_1 7xwa_A_1_B_1 7y75_B_1_C_1 7y75_E_1_F_1 7y76_B_1_C_1 7y76_E_1_F_1 7yhw_A_1_B_1 7yj3_A_1_B_1 7zf7_A_1_B_1 8dm6_B_1_A_1 8dm8_B_1_A_1 8dma_B_1_A_1 8h06_A_1_B_1 8if2_A_1_B_1 8ifz_B_1_A_1 8jyp_B_1_A_1 8kc2_A_1_B_1 8vkp_B_1_A_1 8woy_A_1_B_1 8wrl_A_1_B_1 8wtd_A_1_B_1 [86498 ] 7v61_B_1_C_1 7v61_F_1_G_1 [53268 ] 7xbg_A_1_B_1 [100974:A0A7D6P0R3_9BETC ] 8hxk_A_1_B_1 [63051 ] 8u0t_A_1_B_1 metal [ZN ] 8bn1_A_1_F_1 precipitant [EDO ] 6h5x_A_1_T_1 8df5_F_1_BC_1 [GOL ] 8tos_A_1_J_1


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