Summary for the 330-th Site(N)
PID QueryLength FocusSite TITLE
18353 805 330 N RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 330-th site MUTAGEN: /note="N->Y: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein. In sACE2.v2.2; increases interaction with RBD domain of SARS-CoV-2 spike protein; when associated with Y-27 and L-386."
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
K:49% N:23% S:14% L:8% E:6%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 S (bend) e (exposed) 45.5
3D Complex Information
Predicted Bind Molecules
hetero:235 precipitant:2
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 2ajf_A_1_C_1 2ajf_B_1_D_1 3d0g_A_1_C_1 3d0g_B_1_D_1 3d0h_A_1_C_1 3d0h_B_1_D_1 3d0i_A_1_C_1 3d0i_B_1_D_1 3sci_A_1_C_1 3sci_B_1_D_1 3scj_A_1_C_1 3scj_B_1_D_1 3sck_A_1_C_1 3scl_A_1_C_1 3scl_B_1_D_1 7fc6_A_1_B_1 7wsf_A_1_B_1 7wsg_A_1_B_1 [34874:SPIKE_CVHNL ] 3kbh_A_1_B_1 3kbh_C_1_D_1 3kbh_E_1_F_1 3kbh_G_1_H_1 [100563:SPIKE_CVHSA ] 6acg_D_1_C_1 6acj_D_1_C_1 6ack_D_1_C_1 6cs2_D_1_B_1 [44643:SPIKE_SARS2 ] 6lzg_A_1_B_1 6m0j_A_1_B_1 7c8j_A_1_B_1 7ddo_A_1_B_1 7dhx_A_1_B_1 7e3j_A_1_B_1 7efp_A_1_B_1 7efr_A_1_B_1 7ekc_A_1_B_1 7eke_A_1_B_1 7ekf_A_1_B_1 7ekg_A_1_B_1 7ekh_A_1_B_1 7f5r_A_1_B_1 7f5r_C_1_D_1 7f5r_E_1_F_1 7fc5_B_1_A_1 7fdk_A_1_B_1 7kmb_A_1_B_1 7l0n_I_1_K_1 7l0n_J_1_L_1 7lo4_A_1_B_1 7mjn_B_1_A_1 7nxc_A_1_B_1 7p19_A_1_B_1 7p19_C_1_D_1 7pki_A_1_B_1 7r11_A_1_B_1 7sn0_A_1_C_1 7sn0_B_1_D_1 7sxy_B_1_A_1 7sy0_B_1_A_1 7sy2_B_1_A_1 7sy4_B_1_A_1 7sy6_B_1_A_1 7sy8_B_1_A_1 7tew_B_1_A_1 7tez_B_1_A_1 7vx4_A_1_B_1 7vx5_A_1_B_1 7w6u_A_1_B_1 7wa1_A_1_B_1 7wbq_A_1_B_1 7wbq_C_1_D_1 7wnm_A_1_B_1 7wsh_A_1_B_1 7xa7_A_1_B_1 7xa7_C_1_D_1 7ydi_A_1_B_1 8df5_E_1_K_1 8df5_F_1_L_1 8dlk_B_1_A_1 8dln_B_1_A_1 8dlq_B_1_A_1 8dlv_B_1_A_1 8dv2_B_1_A_1 8ka8_A_1_B_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 6vw1_B_1_D_1 7ufk_A_1_C_1 8sph_B_1_D_1 8spi_A_1_C_1 [100295:SPIKE_SARS2 ] 7a95_D_1_A_1 7a97_D_1_A_1 7a97_E_1_B_1 7a98_B_1_A_1 7a98_C_1_E_1 7a98_D_1_F_1 7ct5_D_1_A_1 7ct5_E_1_B_1 7ct5_F_1_C_1 7edj_D_1_A_1 7edj_E_1_B_1 7edj_F_1_C_1 7fem_D_1_A_1 7kj2_D_1_B_1 7kj3_D_1_B_1 7kj3_E_1_A_1 7kj4_E_1_C_1 7kms_A_1_B_1 7kms_E_1_C_1 7kms_F_1_D_1 7kmz_E_1_D_1 7knb_D_1_C_1 7kne_D_1_C_1 7knh_E_1_D_1 7kni_E_1_B_1 7kni_F_1_C_1 7mjm_D_1_A_1 7mjm_E_1_B_1 7r1a_B_1_E_1 7r1a_D_1_F_1 7sxx_D_1_B_1 7sxz_D_1_B_1 7sy1_D_1_B_1 7sy3_D_1_B_1 7sy5_D_1_A_1 7sy5_E_1_B_1 7sy5_F_1_C_1 7sy7_D_1_B_1 7t9k_D_1_A_1 7t9k_E_1_B_1 7tex_D_1_B_1 7tf0_D_1_B_1 7v85_D_1_A_1 7v86_D_1_A_1 7v88_E_1_C_1 7v89_D_1_A_1 7v89_F_1_C_1 7v8a_E_1_B_1 7v8a_F_1_C_1 7wgb_D_1_C_1 7wk4_A_1_B_1 7wk5_A_1_B_1 7wpa_D_1_A_1 7ws8_D_1_A_1 7ws8_E_1_B_1 7ws9_D_1_A_1 7wvp_A_1_B_1 7xch_D_1_A_1 7xch_E_1_C_1 7xo4_E_1_B_1 7xo5_D_1_A_1 7xo7_D_1_C_1 7xo7_E_1_A_1 7xo8_D_1_A_1 7xo8_E_1_C_1 7xo8_F_1_B_1 7y1y_D_1_A_1 7y1y_E_1_B_1 7y1y_F_1_C_1 7y1z_D_1_B_1 7y1z_E_1_A_1 7y1z_F_1_C_1 7y20_D_1_A_1 7y20_E_1_C_1 7y21_D_1_C_1 7y21_E_1_A_1 7y21_F_1_B_1 7y9z_D_1_A_1 7yeg_D_1_A_1 7yeg_I_1_C_1 7yr2_A_1_B_1 8dlj_D_1_B_1 8dlm_D_1_B_1 8dlp_D_1_A_1 8dlp_E_1_B_1 8dlp_F_1_C_1 8dlu_D_1_A_1 8dlu_E_1_B_1 8dm5_D_1_A_1 8dm5_E_1_B_1 8dm7_D_1_A_1 8dm7_E_1_B_1 8dm9_D_1_A_1 8ify_D_1_C_1 8vkl_D_1_A_1 8vkl_E_1_C_1 8vkm_D_1_A_1 8vko_D_1_A_1 8vko_E_1_B_1 8vko_F_1_C_1 8wgv_F_1_C_1 8wrm_D_1_B_1 8wtj_D_1_B_1 [47457:A0A6G6A1M4_9BETC ] 7ddp_A_1_B_1 7vib_A_1_B_1 7vib_C_1_D_1 [33454:SPIKE_CVHNL ] 7fc3_B_1_A_1 [55210:A0A6B9WHD3_SARS ] 7p8i_A_1_B_1 7p8i_C_1_D_1 7p8j_A_1_B_1 7p8j_C_1_D_1 7w6r_A_1_B_1 [45054:SPIKE_SARS2 ] 7tn0_E_1_I_1 7tn0_F_1_L_1 7wbp_A_1_B_1 7whh_A_1_B_1 7wpb_B_1_A_1 7wpc_C_1_A_1 7wsk_A_1_B_1 7xaz_C_1_D_1 7xb0_A_1_B_1 7xb1_A_1_B_1 7xby_A_1_B_1 7xcp_A_1_B_1 7xo6_A_1_B_1 7xo9_B_1_A_1 7xoc_A_1_B_1 7xwa_A_1_B_1 7yr4_A_1_B_1 8aqs_B_1_A_1 8aqu_A_1_B_1 8aqv_A_1_B_1 8aqw_B_1_A_1 8asy_A_1_B_1 8dm6_B_1_A_1 8dm8_B_1_A_1 8dma_B_1_A_1 8h5c_A_1_B_1 8if2_A_1_B_1 8s9g_A_1_B_1 8vkn_B_1_A_1 8vkp_B_1_A_1 [47407:U5NJG5_MERS ] 7wpo_A_1_B_1 [49292:A0A1W6ASU7_9NIDO ] 7wpz_A_1_B_1 [53268 ] 7xbg_C_1_D_1 [55241:SPIKE_SARS2 ] 8i9f_A_1_B_1 [63051 ] 8u0t_A_1_B_1 precipitant [EDO ] 6en6_D_1_YB_1 [PG4 ] 8qhl_A_1_Q_1


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