Summary for the 325-th Site(Q)
PID QueryLength FocusSite TITLE
18353 805 325 Q RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 325-th site MUTAGEN: /note="Q->P: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
P:45% Q:38% K:14% E:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 S (bend) e (exposed) 76.0
3D Complex Information
Predicted Bind Molecules
hetero:51 otherpoly:2 compound:24 precipitant:1
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 2ajf_A_1_C_1 3d0g_A_1_C_1 3d0g_B_1_D_1 3d0h_A_1_C_1 3sci_A_1_C_1 3sci_B_1_D_1 3scj_A_1_C_1 3scj_B_1_D_1 3sck_A_1_C_1 3sck_B_1_D_1 3scl_A_1_C_1 3scl_B_1_D_1 7wsf_A_1_B_1 7wsg_A_1_B_1 [34874:SPIKE_CVHNL ] 3kbh_A_1_B_1 3kbh_C_1_D_1 3kbh_E_1_F_1 3kbh_G_1_H_1 [100563:SPIKE_CVHSA ] 6acg_D_1_C_1 6acj_D_1_C_1 6ack_D_1_C_1 [100295:SPIKE_SARS2 ] 7a98_C_1_E_1 7kj2_D_1_B_1 7kni_F_1_C_1 7v83_F_1_C_1 7wgb_D_1_C_1 7ws8_D_1_A_1 7ws8_E_1_B_1 7wvq_D_1_C_1 7xch_D_1_A_1 7xo5_D_1_A_1 7ya0_D_1_A_1 7yeg_D_1_A_1 7yeg_I_1_C_1 7yeg_J_1_B_1 8wgv_D_1_A_1 [33454:SPIKE_CVHNL ] 7fc3_B_1_A_1 [44643:SPIKE_SARS2 ] 7l0n_I_1_K_1 7l0n_J_1_L_1 7pki_A_1_B_1 7rpv_A_1_B_1 7rpv_C_1_D_1 7rpv_E_1_F_1 7rpv_G_1_H_1 7vx4_A_1_B_1 8hrl_A_1_B_1 [52893 ] 7ufl_B_1_D_1 8sph_B_1_D_1 8spi_A_1_C_1 8spi_B_1_D_1 [45054:SPIKE_SARS2 ] 7xby_A_1_B_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7v84_B_1_F_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 7wpo_A_1_F_1 compound [NAG ] 7c8k_A_1_F_1 7dqa_A_1_G_1 7kms_E_1_GB_1 7kms_F_1_MB_1 7kmz_C_1_LA_1 7kmz_E_1_FB_1 7knb_D_1_YA_1 7q3y_A_1_N_1 7q4c_A_1_G_1 7r0z_A_1_F_1 7r10_A_1_F_1 7r1a_B_1_W_1 7r1a_C_1_DA_1 7r1a_D_1_KA_1 7v8a_E_1_GB_1 7wbl_A_1_F_1 7wpa_D_1_LA_1 7wpz_A_1_G_1 7ws9_D_1_BA_1 7zf7_A_1_C_1 8asy_A_1_D_1 8dlq_B_1_G_1 8u0t_A_1_G_1 8wgv_F_1_DB_1 precipitant [BO3 ] 6zpq_A_1_N_1


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