Summary for the 324-th Site(T)
PID QueryLength FocusSite TITLE
18353 805 324 T RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 324-th site MUTAGEN: /note="T->A: No effect on interaction with SARS-CoV spike glycoprotein."
MUTAGEN: /note="T->P: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
P:74% T:23% S:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 (coil) e (exposed) 35.7
3D Complex Information
Predicted Bind Molecules
hetero:36 compound:6 metal:1
Templates for 3D complexes
hetero [34874:SPIKE_CVHNL ] 3kbh_A_1_B_1 3kbh_C_1_D_1 3kbh_E_1_F_1 3kbh_G_1_H_1 [33454:SPIKE_CVHNL ] 7fc3_B_1_A_1 [44643:SPIKE_SARS2 ] 7fdh_A_1_B_1 7l0n_I_1_K_1 [100295:SPIKE_SARS2 ] 7kj3_D_1_B_1 7kj3_E_1_A_1 7kj4_E_1_C_1 7kj4_F_1_A_1 7v7z_F_1_C_1 7v85_D_1_A_1 7wgb_E_1_B_1 7wk4_A_1_B_1 7wk5_A_1_B_1 7ws8_D_1_A_1 7wvp_A_1_B_1 7wvq_D_1_C_1 7xch_D_1_A_1 7xch_E_1_C_1 7xo4_E_1_B_1 7xo5_D_1_A_1 7yeg_D_1_A_1 7yeg_I_1_C_1 7yeg_J_1_B_1 7yr2_A_1_B_1 8ify_E_1_A_1 8wgv_D_1_A_1 8wgv_E_1_B_1 8wrm_D_1_B_1 [45054:SPIKE_SARS2 ] 7wbl_A_1_B_1 7xcp_A_1_B_1 7yr4_A_1_B_1 8wrl_A_1_B_1 [44550:SPIKE_SARS ] 7wsg_A_1_B_1 compound [NAG ] 7dqa_A_1_G_1 7wpa_D_1_LA_1 7zf7_A_1_C_1 8asy_A_1_D_1 8wgv_D_1_TA_1 8wgv_F_1_DB_1 metal [CL ] 7u0n_B_1_CA_1


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