Summary for the 26-th Site(K)
PID QueryLength FocusSite TITLE
18353 805 26 K RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 26-th site VARIANT: /note="K -> R (in dbSNP:rs4646116)" /id="VAR_023082"
MUTAGEN: /note="QAK->KAE: Slightly inhibits interaction with SARS- CoV spike glycoprotein."
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
VARIANT for 26-th site K->R LB/B dbSNP:rs4646116 " -"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
K:38% R:22% S:10% Q:6% E:6% T:6% V:5% N:3% D:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 H (alpha-helix) e (exposed) 34.4
3D Complex Information
Predicted Bind Molecules
hetero:8 otherpoly:109 compound:96 metal:1
Templates for 3D complexes
hetero [100295:SPIKE_SARS2 ] 7a97_E_1_B_1 7wk5_A_1_B_1 7ws8_D_1_A_1 7wvp_A_1_B_1 7xo4_D_1_A_1 7xo4_E_1_B_1 8t22_D_1_C_1 [56290 ] 8e7m_A_1_B_1 otherpoly [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 2ajf_A_1_E_1 2ajf_B_1_F_1 6vw1_A_1_E_1 7u0n_A_1_F_1 7u0n_B_1_H_1 7ufk_A_1_F_1 7xb0_A_1_C_1 7xwa_A_1_F_1 8iov_A_1_E_1 8jyn_D_1_M_1 8jyo_D_1_N_1 8jyo_E_1_Q_1 8jyp_B_1_D_1 8sph_A_1_E_1 8spi_A_1_F_1 [beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 2iul_A_1_B_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 2xy9_A_1_B_1 4bzr_A_1_B_1 4c2o_A_1_B_1 4c2p_A_1_B_1 4c2q_A_1_B_1 6h5w_A_1_C_1 7q27_A_1_B_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 3bkk_A_1_B_1 3bkl_A_1_B_1 3l3n_A_1_B_1 4ca5_A_1_B_1 8e7m_A_1_D_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 6f9t_A_1_C_1 [alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 6f9u_A_1_B_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 6m17_B_1_I_1 6m17_E_1_Q_1 6m18_B_1_G_1 6m18_D_1_N_1 6vw1_B_1_I_1 7drv_A_1_E_1 7drv_C_1_G_1 7dwx_B_1_M_1 7dwx_D_1_T_1 7dx5_D_1_AA_1 7dx6_D_1_BA_1 7dx7_D_1_BA_1 7dx8_D_1_CA_1 7dx8_E_1_HA_1 7dx9_D_1_CA_1 7dx9_E_1_HA_1 7ekc_A_1_C_1 7ekg_A_1_C_1 7fc3_B_1_D_1 7kj3_D_1_Q_1 7kj4_E_1_V_1 7p8i_C_1_J_1 7pki_A_1_C_1 7ufk_B_1_H_1 7v61_B_1_K_1 7v61_F_1_R_1 7v8b_B_1_D_1 7wbq_A_1_E_1 7wbq_C_1_G_1 7xaz_C_1_E_1 7xb1_A_1_C_1 7xbg_C_1_E_1 7y1y_E_1_JA_1 7y1y_F_1_OA_1 7y1z_D_1_EA_1 7y1z_E_1_JA_1 7y1z_F_1_OA_1 7y20_D_1_DA_1 7y20_E_1_IA_1 7y21_D_1_EA_1 7y21_E_1_JA_1 7y21_F_1_OA_1 7y75_B_1_I_1 7y75_E_1_Q_1 7y76_B_1_I_1 7y76_E_1_Q_1 8i91_A_1_F_1 8i91_C_1_M_1 8i92_A_1_F_1 8i92_C_1_M_1 8i93_A_1_F_1 8i93_C_1_M_1 8i9b_D_1_DA_1 8i9b_E_1_IA_1 8i9b_F_1_NA_1 8i9c_D_1_EA_1 8i9c_E_1_JA_1 8i9c_F_1_OA_1 8i9d_D_1_EA_1 8i9d_E_1_JA_1 8i9d_F_1_OA_1 8i9e_A_1_D_1 8i9f_A_1_D_1 8i9g_A_1_D_1 8i9h_A_1_D_1 8sph_B_1_I_1 8spi_B_1_I_1 8tor_A_1_D_1 8tot_A_1_F_1 8tot_B_1_H_1 [alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 7q28_A_1_B_1 7q29_A_1_B_1 7z70_A_1_B_1 [beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7sn0_A_1_I_1 [beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7sn0_B_1_O_1 [alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 7whh_A_1_C_1 [alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7xwa_C_1_J_1 [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 8if2_A_1_D_1 [alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 8tos_A_1_C_1 compound [NAG ] 1r42_A_1_F_1 1r4l_A_1_F_1 3kbh_A_1_I_1 3kbh_C_1_M_1 3kbh_E_1_Q_1 3kbh_G_1_U_1 6lzg_A_1_D_1 6m0j_A_1_F_1 7a91_A_1_E_1 7a92_A_1_E_1 7c8k_A_1_D_1 7ddp_A_1_E_1 7dhx_A_1_D_1 7efp_A_1_D_1 7efr_A_1_D_1 7eke_A_1_D_1 7ekf_A_1_E_1 7ekh_A_1_D_1 7fdg_A_1_F_1 7fdi_A_1_D_1 7knb_D_1_BB_1 7kni_D_1_EB_1 7l0n_I_1_MA_1 7l0n_J_1_TA_1 7lo4_A_1_E_1 7mjm_D_1_WA_1 7mjm_E_1_AB_1 7nxc_A_1_D_1 7p19_A_1_E_1 7r10_A_1_E_1 7r12_A_1_E_1 7rpv_A_1_J_1 7rpv_E_1_X_1 7rpv_G_1_EA_1 7sxx_D_1_RA_1 7sy5_E_1_DB_1 7sy7_D_1_TA_1 7sy8_B_1_E_1 7t9l_B_1_E_1 7tew_B_1_E_1 7tex_D_1_RA_1 7tn0_E_1_GA_1 7vx4_A_1_E_1 7vx5_A_1_E_1 7wbl_A_1_E_1 7wbp_A_1_E_1 7wpb_B_1_E_1 7wpc_C_1_H_1 7ws8_D_1_CA_1 7ws8_E_1_IA_1 7ws9_D_1_Z_1 7wsa_B_1_E_1 7xaz_A_1_G_1 7xbf_C_1_M_1 7xbh_B_1_E_1 7xch_D_1_TA_1 7xci_A_1_G_1 7xcp_A_1_G_1 7xo7_D_1_QA_1 7xo7_E_1_VA_1 7xo8_D_1_QA_1 7xo8_E_1_UA_1 7xo8_F_1_YA_1 7xo9_B_1_G_1 7ya0_E_1_UA_1 7ya0_F_1_AB_1 7ya1_A_1_E_1 7ydi_A_1_F_1 7zf7_A_1_G_1 8aqs_B_1_E_1 8asy_A_1_I_1 8df5_E_1_IA_1 8df5_F_1_YA_1 8dlj_D_1_TA_1 8dlm_D_1_RA_1 8dlp_E_1_DB_1 8dlq_B_1_E_1 8dlu_E_1_CB_1 8dm5_D_1_TA_1 8dm6_B_1_E_1 8hfz_D_1_VA_1 8vko_D_1_AB_1 8vko_E_1_EB_1 8vko_F_1_IB_1 8vkp_B_1_G_1 8wgv_D_1_WA_1 8wgv_F_1_GB_1 8wgw_B_1_H_1 8wrh_A_1_D_1 8wrl_A_1_D_1 8wtd_A_1_D_1 [NDG ] 3d0g_B_1_H_1 3d0h_A_1_E_1 3d0h_B_1_H_1 3d0i_A_1_E_1 3d0i_B_1_H_1 metal [CL ] 7l0n_I_1_QA_1


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