Summary for the 19-th Site(S)
PID QueryLength FocusSite TITLE
18353 805 19 S RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 19-th site MUTAGEN: /note="S->P: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
S:59% A:12% L:11% T:9% V:9%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 (coil) e (exposed) 48.4
3D Complex Information
Predicted Bind Molecules
hetero:247
Templates for 3D complexes
hetero [44550:SPIKE_CVHSA ] 2ajf_B_1_D_1 3d0g_A_1_C_1 3d0g_B_1_D_1 3d0h_A_1_C_1 3d0h_B_1_D_1 3d0i_A_1_C_1 3d0i_B_1_D_1 3sci_A_1_C_1 3sci_B_1_D_1 3scj_A_1_C_1 3scj_B_1_D_1 3sck_A_1_C_1 3sck_B_1_D_1 3scl_A_1_C_1 3scl_B_1_D_1 7fc6_A_1_B_1 7wsf_A_1_B_1 7wsg_A_1_B_1 8woz_A_1_B_1 [100563:SPIKE_CVHSA ] 6acj_D_1_C_1 6cs2_D_1_B_1 [44643:SPIKE_SARS2 ] 6lzg_A_1_B_1 7a91_A_1_B_1 7dhx_A_1_B_1 7dmu_C_1_D_1 7dx4_A_1_B_1 7ekc_A_1_B_1 7eke_A_1_B_1 7ekf_A_1_B_1 7ekg_A_1_B_1 7ekh_A_1_B_1 7f5r_A_1_B_1 7fdi_A_1_B_1 7l0n_I_1_K_1 7l0n_J_1_L_1 7lo4_A_1_B_1 7nxc_A_1_B_1 7pki_A_1_B_1 7r0z_A_1_B_1 7r12_A_1_B_1 7rpv_A_1_B_1 7rpv_C_1_D_1 7rpv_E_1_F_1 7rpv_G_1_H_1 7sxy_B_1_A_1 7sy0_B_1_A_1 7sy2_B_1_A_1 7sy4_B_1_A_1 7sy6_B_1_A_1 7sy8_B_1_A_1 7tew_B_1_A_1 7tez_B_1_A_1 7wa1_A_1_B_1 7wbq_C_1_D_1 7wnm_A_1_B_1 7wse_A_1_B_1 7xa7_A_1_B_1 7zdq_A_1_B_1 8df5_E_1_K_1 8df5_F_1_L_1 8dlk_B_1_A_1 8dln_B_1_A_1 8dlq_B_1_A_1 8dlv_B_1_A_1 [52893:SPIKE_CVHSA :SPIKE_SARS2 :SPIKE_CVHSA ] 6vw1_A_1_C_1 6vw1_B_1_D_1 7u0n_A_1_C_1 7u0n_B_1_D_1 7ufk_A_1_C_1 7ufk_B_1_D_1 8sph_A_1_C_1 8sph_B_1_D_1 8spi_A_1_C_1 8spi_B_1_D_1 [95898:SPIKE_SARS2 ] 7a92_A_1_B_1 7r10_A_1_B_1 [100295:SPIKE_SARS2 ] 7a94_D_1_A_1 7a95_D_1_A_1 7a96_D_1_A_1 7a97_D_1_A_1 7a97_E_1_B_1 7a98_B_1_A_1 7a98_C_1_E_1 7a98_D_1_F_1 7df4_A_1_C_1 7edj_D_1_A_1 7edj_E_1_B_1 7edj_F_1_C_1 7fem_D_1_A_1 7knb_D_1_C_1 7kni_D_1_A_1 7r1a_C_1_A_1 7sxx_D_1_B_1 7sxz_D_1_B_1 7sy1_D_1_B_1 7sy3_D_1_B_1 7sy5_D_1_A_1 7sy5_E_1_B_1 7sy5_F_1_C_1 7sy7_D_1_B_1 7t9k_D_1_A_1 7t9k_E_1_B_1 7tex_D_1_B_1 7tf0_D_1_B_1 7v7z_D_1_A_1 7v81_E_1_C_1 7v82_E_1_A_1 7v82_F_1_C_1 7v83_D_1_A_1 7v83_E_1_B_1 7v83_F_1_C_1 7v85_D_1_A_1 7v85_E_1_B_1 7v86_D_1_A_1 7v86_E_1_B_1 7v86_F_1_C_1 7v88_D_1_A_1 7v88_E_1_C_1 7v89_D_1_A_1 7v89_E_1_B_1 7v89_F_1_C_1 7v8a_D_1_A_1 7v8a_E_1_B_1 7v8a_F_1_C_1 7w98_C_1_D_1 7w99_C_1_D_1 7w9b_C_1_D_1 7w9c_C_1_D_1 7wgb_D_1_C_1 7wgb_E_1_B_1 7wpa_D_1_A_1 7ws8_D_1_A_1 7ws8_E_1_B_1 7ws9_D_1_A_1 7wvq_D_1_C_1 7xch_D_1_A_1 7xch_E_1_C_1 7xid_D_1_C_1 7xid_E_1_B_1 7xo8_D_1_A_1 7xo8_E_1_C_1 7xo8_F_1_B_1 7y1y_D_1_A_1 7y1y_E_1_B_1 7y1y_F_1_C_1 7y1z_D_1_B_1 7y1z_E_1_A_1 7y1z_F_1_C_1 7y20_D_1_A_1 7y20_E_1_C_1 7y21_D_1_C_1 7y21_E_1_A_1 7y21_F_1_B_1 7y9z_D_1_A_1 7ya0_D_1_A_1 7ya0_F_1_C_1 7yr2_A_1_B_1 8dlj_D_1_B_1 8dlm_D_1_B_1 8dlp_D_1_A_1 8dlp_E_1_B_1 8dlp_F_1_C_1 8dlu_D_1_A_1 8dlu_E_1_B_1 8hfz_D_1_A_1 8i9b_D_1_C_1 8i9b_E_1_A_1 8i9b_F_1_B_1 8i9d_D_1_C_1 8i9d_E_1_A_1 8i9d_F_1_B_1 8iou_D_1_A_1 8jyn_D_1_A_1 8jyo_D_1_B_1 8jyo_E_1_A_1 8t20_D_1_C_1 8taz_D_1_A_1 8wgv_D_1_A_1 8wgv_E_1_B_1 8wgv_F_1_C_1 8wlo_D_1_A_1 8wrm_D_1_B_1 8wro_D_1_B_1 8wtj_D_1_B_1 [48937:SPIKE_SARS2 ] 7bh9_A_1_B_1 [55210:A0A6B9WHD3_SARS ] 7drv_A_1_B_1 7drv_C_1_D_1 7p8i_A_1_B_1 7p8j_C_1_D_1 7w6r_A_1_B_1 [51988 ] 7e7e_D_1_F_1 [45054:SPIKE_SARS2 ] 7t9l_B_1_A_1 7tn0_E_1_I_1 7tn0_F_1_L_1 7wbl_A_1_B_1 7wbp_A_1_B_1 7wgc_A_1_B_1 7whh_A_1_B_1 7wk6_B_1_A_1 7wpb_B_1_A_1 7wpc_C_1_A_1 7wri_A_1_B_1 7wsa_B_1_A_1 7wsk_A_1_B_1 7xaz_A_1_B_1 7xaz_C_1_D_1 7xb0_A_1_B_1 7xb1_A_1_B_1 7xby_A_1_B_1 7xci_A_1_B_1 7xcp_A_1_B_1 7xo9_B_1_A_1 7xwa_A_1_B_1 7xwa_C_1_D_1 7y75_B_1_C_1 7y75_E_1_F_1 7y76_B_1_C_1 7y76_E_1_F_1 7yhw_A_1_B_1 7yj3_A_1_B_1 7zf7_A_1_B_1 8aqs_B_1_A_1 8asy_A_1_B_1 8dm6_B_1_A_1 8fxc_C_1_D_1 8h06_A_1_B_1 8h5c_A_1_B_1 8hfy_B_1_A_1 8i9h_A_1_B_1 8if2_A_1_B_1 8jyp_B_1_A_1 8vkp_B_1_A_1 8wgw_B_1_A_1 8woy_A_1_B_1 8wrh_A_1_B_1 8wrl_A_1_B_1 8wtd_A_1_B_1 [51336 ] 7v61_B_1_D_1 7v61_F_1_H_1 [53268 ] 7xbf_C_1_D_1 7xbg_A_1_B_1 7xbg_C_1_D_1 7xbh_B_1_A_1 [49624 ] 8e7m_A_1_C_1 [61398:SPIKE_SARS2 ] 8fxb_C_1_D_1 [55241:SPIKE_SARS2 ] 8i9e_A_1_B_1 8i9f_A_1_B_1


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