Summary for the 392-nd Site(H)
PID QueryLength FocusSite TITLE
3025 967 392 H RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
UniProt Information
AC/IDAC:P15144 ID:AMPN_HUMAN
Feature Table for 392-th site BINDING: /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" ECO:0007744|PDB:4FYQ, ECO:0007744|PDB:4FYR, ECO:0007744|PDB:4FYT"
MUTAGEN: /note="H->A: Loss of aminopeptidase activity."
HELIX:
REGION: /note="Metalloprotease"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Aminopeptidase N" /id="PRO_0000095081"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
H:89% A:11%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5lhd T (Hbond turn) b (buried) 0.5
3D Complex Information
Predicted Bind Molecules
hetero:21 compound:209 metal:385 precipitant:25
Templates for 3D complexes
hetero [25 ] 3b7s_A_1_B_1 [51 ] 3b7t_A_1_B_1 [1187 ] 4fyt_A_1_B_1 4fyt_A_2_B_2 4kx8_A_1_B_1 4q4i_A_1_B_1 [396 ] 4wz9_A_1_C_1 [7475 ] 4z7i_A_1_C_1 [7336 ] 4z7i_B_1_D_1 [9288 ] 5ab0_A_1_C_1 5ab0_B_1_D_1 [592 ] 5ab2_A_1_C_1 5ab2_B_1_D_1 [61 ] 6enb_A_1_B_1 [101 ] 6ifg_A_1_C_1 6ifg_B_1_D_1 [7645 ] 6mgq_A_1_D_1 6mgq_B_1_E_1 6mgq_C_1_F_1 [4629 ] 6rqx_A_1_B_1 [7578 ] 6ryf_A_1_B_1 compound [BES ] 1gw6_A_1_B_1 1hs6_A_1_G_1 2dqm_A_1_E_1 2hpt_A_1_C_1 2xq0_A_1_B_1 2yd0_A_1_I_1 3ebh_A_1_C_1 3ftx_A_1_G_1 3fue_A_1_G_1 3fuf_A_1_G_1 3fuh_A_1_G_1 3mdj_A_1_H_1 3mdj_B_1_L_1 3mdj_C_1_O_1 4fkk_A_1_M_1 4fyr_A_1_L_1 4fyr_A_2_L_2 4gaa_A_1_D_1 4gaa_B_1_F_1 4kxb_A_1_J_1 4xmx_A_1_C_1 [PH0 ] 2r59_A_1_D_1 [HA2 ] 2vj8_A_1_G_1 [S23 ] 2zxg_A_1_C_1 [ARG ] 3b2p_A_1_E_1 4j3b_A_1_B_1 4xmv_A_1_C_1 6kp0_A_1_D_1 6kp0_B_1_G_1 [LYS ] 3b2x_A_1_E_1 3se6_A_1_G_1 3se6_B_1_K_1 4e36_A_1_G_1 4e36_B_1_M_1 6ea4_A_1_M_1 [PHE ] 3b34_A_1_E_1 4xn5_A_1_C_1 [TYR ] 3b37_A_1_E_1 6a8z_A_1_D_1 6a8z_B_1_G_1 6iff_A_1_D_1 6iff_B_1_G_1 [TRP ] 3b3b_A_1_E_1 6koy_A_1_C_1 6koy_B_1_E_1 [BIR ] 3b7r_A_1_E_1 [KEL ] 3b7u_A_1_G_1 [4BQ ] 3chq_A_1_G_1 [4BU ] 3chs_A_1_G_1 [BEY ] 3ebi_A_1_C_1 [25P ] 3fh7_A_1_H_1 [28P ] 3fhe_A_1_H_1 3u9w_A_1_I_1 [58Z ] 3fuk_A_1_D_1 [DAB ] 3ked_A_1_C_1 4xmz_A_1_K_1 [D66 ] 3q43_A_1_K_1 [D50 ] 3q44_A_1_C_1 [SER ] 3qjx_A_1_F_1 [BTJ ] 3t8v_A_1_F_1 [P52 ] 4jbs_A_1_K_1 6m8p_A_1_PB_1 6m8p_B_1_FC_1 6m8p_C_1_WC_1 6m8p_D_1_OD_1 6m8p_E_1_FE_1 6m8p_F_1_WE_1 6m8p_G_1_MF_1 6m8p_H_1_FG_1 6m8p_I_1_WG_1 6m8p_J_1_MH_1 6m8p_K_1_CI_1 6m8p_L_1_WI_1 6m8p_M_1_NJ_1 6m8p_N_1_FK_1 6m8p_O_1_VK_1 6m8p_P_1_ML_1 6m8p_Q_1_CM_1 6m8p_R_1_SM_1 6m8p_S_1_LN_1 6m8p_T_1_CO_1 6m8p_U_1_TO_1 6m8p_V_1_KP_1 [19N ] 4k5l_A_1_C_1 [1OV ] 4k5m_A_1_G_1 [1OU ] 4k5n_A_1_G_1 [1OT ] 4k5o_A_1_G_1 [1OS ] 4k5p_A_1_G_1 [28T ] 4mkt_A_1_C_1 4ms6_A_1_C_1 7llq_A_1_F_1 7llq_B_1_I_1 7llq_C_1_L_1 [PLU ] 4pu2_A_1_B_1 [2WW ] 4pvb_A_1_B_1 [2X0 ] 4pw4_A_1_B_1 [BB2 ] 4q4e_A_1_C_1 5y1x_A_1_D_1 [32Q ] 4qhp_A_1_B_1 [379 ] 4qir_A_1_B_1 [37B ] 4qme_A_1_B_1 [37E ] 4qpe_A_1_B_1 [3DZ ] 4quo_A_1_B_1 [R5T ] 4r5t_A_1_M_1 [R5V ] 4r5v_A_1_C_1 [R5X ] 4r5x_A_1_H_1 [SHH ] 4r7l_A_1_J_1 [B3N ] 4rsy_A_1_B_1 [TOD ] 4x2u_A_1_C_1 [DPP ] 4xmt_A_1_C_1 4xn7_A_1_C_1 [ASP ] 4xmw_A_1_C_1 5zie_A_1_C_1 5zie_B_1_D_1 [GLU ] 4xn1_A_1_C_1 4xo5_A_1_C_1 5zi7_A_1_C_1 5zi7_B_1_D_1 [LEU ] 4xn2_A_1_C_1 4xo3_A_1_C_1 6koz_A_1_D_1 [MET ] 4xn4_A_1_C_1 4xo4_A_1_E_1 6kp1_A_1_E_1 6kp1_B_1_H_1 [B3K ] 4xna_A_1_C_1 [3FB ] 4xnb_A_1_C_1 [HT7 ] 4xnd_A_1_C_1 [4QP ] 4zqt_A_1_B_1 [4S9 ] 4zw3_A_1_B_1 [4SA ] 4zw5_A_1_C_1 [4SY ] 4zw6_A_1_B_1 [4SZ ] 4zw7_A_1_C_1 [4T2 ] 4zw8_A_1_C_1 [4TK ] 4zx3_A_1_C_1 [4TL ] 4zx4_A_1_B_1 [4TM ] 4zx5_A_1_C_1 [4U6 ] 4zx6_A_1_C_1 [A4Z ] 5bpp_A_1_G_1 [5HR ] 5dyf_A_1_M_1 [6GA ] 5j6s_A_1_O_1 5j6s_B_1_V_1 [6PX ] 5k1v_A_1_G_1 [7MK ] 5mfr_A_1_C_1 [7ML ] 5mfs_A_1_C_1 6sbq_A_1_C_1 [7MF ] 5mft_A_1_C_1 6g8b_A_1_F_1 [7O2 ] 5mj6_A_1_X_1 5mj6_B_1_XA_1 [DJ3 ] 5ni2_A_1_E_1 5ni4_A_1_H_1 5ni4_B_1_M_1 5ni4_C_1_P_1 [89X ] 5xm7_A_1_Q_1 [8KO ] 5y19_A_1_F_1 [E8C ] 5y1h_A_1_I_1 [B1B ] 5y1k_A_1_L_1 [8L0 ] 5y1q_A_1_F_1 [8KR ] 5y1r_A_1_G_1 [E8F ] 5y1s_A_1_F_1 [E8G ] 5y1t_A_1_F_1 [8LO ] 5y1v_A_1_E_1 [8N3 ] 5y3i_A_1_F_1 [0A1 ] 5yq1_A_1_C_1 5yqb_A_1_C_1 [J0Y ] 6ea1_A_1_C_1 [J1G ] 6ea2_A_1_C_1 [J1V ] 6eaa_A_1_C_1 [J2D ] 6eab_A_1_C_1 [J4V ] 6ee3_A_1_C_1 [J4S ] 6ee4_A_1_C_1 [J4P ] 6ee6_A_1_C_1 [J6A ] 6eed_A_1_C_1 [BGW ] 6enc_A_1_H_1 [HJ5 ] 6q4r_A_1_G_1 [L5E ] 6sbr_A_1_C_1 [MLT ] 6t6r_A_1_C_1 8cgp_A_1_Y_1 8cgp_B_1_JA_1 [ONN ] 6ydx_A_1_J_1 6ydx_B_1_W_1 [RZE ] 7auz_A_1_I_1 [RZB ] 7av0_A_1_I_1 [UQE ] 7nsk_A_1_S_1 7nsk_B_1_BA_1 [USK ] 7nup_A_1_AA_1 7nup_B_1_PA_1 7nup_C_1_YA_1 7nup_D_1_GB_1 [62S ] 7p7p_A_1_J_1 7p7p_B_1_CA_1 [7OO ] 7pfs_A_1_Q_1 7pfs_B_1_W_1 [GIY ] 7sh0_A_1_D_1 7sh0_B_1_J_1 [I88 ] 7z28_A_1_E_1 [KFR ] 7zyf_A_1_Q_1 7zyf_B_1_KA_1 [X0I ] 8ewz_A_1_B_1 [X10 ] 8ex3_A_1_C_1 [X4O ] 8eyd_A_1_C_1 [X4I ] 8eye_A_1_G_1 [X4T ] 8eyf_A_1_C_1 [X68 ] 8ez2_A_1_D_1 [WID ] 8qow_A_1_H_1 [WSL ] 8qpn_A_1_I_1 [WEE ] 8qq4_A_1_I_1 [BYW ] 8slo_A_1_C_1 metal [ZN ] 1gw6_A_1_F_1 1h19_A_1_B_1 1hs6_A_1_B_1 1sqm_A_1_B_1 1z1w_A_1_B_1 1z5h_A_1_P_1 1z5h_A_2_P_2 1z5h_B_1_U_1 1z5h_B_3_U_3 1z5h_B_4_U_4 2dq6_A_1_B_1 2dqm_A_1_B_1 2gtq_A_1_B_1 2hpo_A_1_B_1 2hpt_A_1_B_1 2r59_A_1_B_1 2vj8_A_1_B_1 2xpy_A_1_C_1 2xpz_A_1_C_1 2xq0_A_1_C_1 2yd0_A_1_E_1 2zxg_A_1_B_1 3b2p_A_1_B_1 3b2x_A_1_B_1 3b34_A_1_B_1 3b37_A_1_B_1 3b3b_A_1_B_1 3b7r_A_1_B_1 3b7s_A_1_C_1 3b7t_A_1_C_1 3b7u_A_1_B_1 3cho_A_1_B_1 3chp_A_1_B_1 3chq_A_1_B_1 3chr_A_1_B_1 3chs_A_1_B_1 3cia_A_1_E_1 3cia_B_1_F_1 3cia_C_1_G_1 3cia_D_1_H_1 3ebg_A_1_B_1 3ebh_A_1_B_1 3ebi_A_1_B_1 3fh5_A_1_B_1 3fh7_A_1_B_1 3fh8_A_1_B_1 3fhe_A_1_B_1 3fts_A_1_B_1 3ftu_A_1_B_1 3ftv_A_1_B_1 3ftw_A_1_B_1 3ftx_A_1_B_1 3fty_A_1_B_1 3ftz_A_1_B_1 3fu0_A_1_B_1 3fu3_A_1_B_1 3fu5_A_1_B_1 3fu6_A_1_B_1 3fud_A_1_B_1 3fue_A_1_B_1 3fuf_A_1_B_1 3fuh_A_1_B_1 3fui_A_1_E_1 3fuj_A_1_B_1 3fuk_A_1_B_1 3ful_A_1_B_1 3fum_A_1_B_1 3fun_A_1_B_1 3ked_A_1_B_1 3mdj_A_1_G_1 3mdj_B_1_K_1 3mdj_C_1_N_1 3puu_A_1_B_1 3q43_A_1_B_1 3q44_A_1_B_1 3q7j_A_1_C_1 3q7j_B_1_E_1 3qjx_A_1_B_1 3qnf_A_1_E_1 3qnf_B_1_F_1 3qnf_C_1_I_1 3se6_A_1_F_1 3se6_B_1_L_1 3t8v_A_1_B_1 3u9w_A_1_B_1 4dpr_A_1_B_1 4e36_A_1_L_1 4e36_B_1_N_1 4f5c_A_1_H_1 4f5c_B_1_R_1 4fke_A_1_M_1 4fkh_A_1_N_1 4fkk_A_1_N_1 4fyq_A_1_J_1 4fyq_A_2_J_2 4fyr_A_1_K_1 4fyr_A_2_K_2 4fyt_A_1_K_1 4fyt_A_2_K_2 4gaa_A_1_C_1 4gaa_B_1_E_1 4hom_A_1_N_1 4j3b_A_1_C_1 4jbs_A_1_J_1 4jbs_B_1_P_1 4k5l_A_1_B_1 4k5m_A_1_B_1 4k5n_A_1_B_1 4k5o_A_1_D_1 4k5p_A_1_B_1 4kx7_A_1_G_1 4kx8_A_1_H_1 4kx9_A_1_H_1 4kxa_A_1_I_1 4kxb_A_1_H_1 4kxc_A_1_H_1 4kxd_A_1_I_1 4l2l_A_1_B_1 4mkt_A_1_B_1 4ms6_A_1_B_1 4naq_A_1_X_1 4nz8_A_1_N_1 4ou3_A_1_K_1 4ou3_A_2_K_2 4p8q_A_1_H_1 4p8q_B_1_P_1 4pj6_A_1_D_1 4pj6_B_1_M_1 4pu2_A_1_E_1 4pvb_A_1_C_1 4pw4_A_1_C_1 4q4e_A_1_B_1 4q4i_A_1_C_1 4qhp_A_1_I_1 4qir_A_1_J_1 4qme_A_1_C_1 4qpe_A_1_C_1 4quo_A_1_H_1 4r5t_A_1_B_1 4r5v_A_1_B_1 4r5x_A_1_B_1 4r7l_A_1_B_1 4rsy_A_1_C_1 4rvb_A_1_C_1 4wz9_A_1_E_1 4wz9_B_1_I_1 4x2u_A_1_B_1 4xmt_A_1_B_1 4xmu_A_1_B_1 4xmv_A_1_B_1 4xmw_A_1_B_1 4xmx_A_1_B_1 4xmz_A_1_B_1 4xn1_A_1_B_1 4xn2_A_1_B_1 4xn4_A_1_B_1 4xn5_A_1_B_1 4xn7_A_1_B_1 4xn8_A_1_B_1 4xn9_A_1_B_1 4xna_A_1_B_1 4xnb_A_1_B_1 4xnd_A_1_B_1 4xo3_A_1_B_1 4xo4_A_1_B_1 4xo5_A_1_B_1 4z7i_A_1_K_1 4z7i_B_1_S_1 4zqt_A_1_C_1 4zw3_A_1_C_1 4zw5_A_1_B_1 4zw6_A_1_C_1 4zw7_A_1_B_1 4zw8_A_1_B_1 4zx3_A_1_B_1 4zx4_A_1_C_1 4zx5_A_1_B_1 4zx6_A_1_B_1 5ab0_A_1_K_1 5ab0_B_1_Y_1 5ab2_A_1_Q_1 5ab2_B_1_X_1 5aen_A_1_C_1 5bpp_A_1_B_1 5c97_A_1_H_1 5c97_B_1_R_1 5dll_A_1_B_1 5dyf_A_1_B_1 5fwq_A_1_C_1 5j6s_A_1_H_1 5j6s_B_1_P_1 5k1v_A_1_F_1 5k1v_B_1_N_1 5lds_A_1_T_1 5lds_B_1_Y_1 5lds_C_1_EA_1 5lds_C_2_EA_2 5lds_D_1_LA_1 5lds_D_3_LA_3 5lg6_A_1_L_1 5lg6_B_1_V_1 5lhd_A_1_JA_1 5lhd_B_1_CB_1 5lhd_C_1_QB_1 5lhd_D_1_FC_1 5mfr_A_1_B_1 5mfs_A_1_B_1 5mft_A_1_B_1 5mj6_A_1_W_1 5mj6_B_1_WA_1 5n3w_A_1_B_1 5ni2_A_1_B_1 5ni4_A_1_D_1 5ni4_B_1_I_1 5ni4_C_1_N_1 5ni6_A_1_B_1 5nia_A_1_B_1 5nid_A_1_B_1 5nie_A_1_D_1 5nie_B_1_E_1 5nie_C_1_F_1 5xm7_A_1_B_1 5y19_A_1_B_1 5y1h_A_1_E_1 5y1k_A_1_B_1 5y1q_A_1_B_1 5y1r_A_1_B_1 5y1s_A_1_B_1 5y1t_A_1_B_1 5y1v_A_1_B_1 5y1w_A_1_B_1 5y1x_A_1_B_1 5y3i_A_1_B_1 5yo1_A_1_B_1 5yq1_A_1_B_1 5yq2_A_1_B_1 5yqb_A_1_B_1 5z65_A_1_K_1 5zi5_A_1_C_1 5zi5_B_1_D_1 6a8z_A_1_C_1 6a8z_B_1_F_1 6atk_A_1_P_1 6atk_B_1_U_1 6atk_C_1_Y_1 6buy_A_1_X_1 6bv0_A_1_X_1 6bv1_A_1_X_1 6bv2_A_1_X_1 6bv3_A_1_Y_1 6bv4_A_1_Z_1 6ea1_A_1_B_1 6ea2_A_1_B_1 6ea4_A_1_J_1 6ea4_B_1_V_1 6eaa_A_1_B_1 6eab_A_1_B_1 6ee3_A_1_B_1 6ee4_A_1_B_1 6ee6_A_1_B_1 6eed_A_1_B_1 6enb_A_1_C_1 6enc_A_1_B_1 6end_A_1_B_1 6g8b_A_1_B_1 6iff_A_1_C_1 6iff_B_1_F_1 6ifg_A_1_E_1 6ifg_B_1_N_1 6koy_A_1_D_1 6koy_B_1_F_1 6koz_A_1_C_1 6koz_B_1_F_1 6kp0_A_1_C_1 6kp0_B_1_F_1 6kp1_A_1_C_1 6kp1_B_1_F_1 6m8p_A_1_OB_1 6m8p_B_1_EC_1 6m8p_C_1_VC_1 6m8p_D_1_ND_1 6m8p_E_1_EE_1 6m8p_F_1_VE_1 6m8p_G_1_LF_1 6m8p_H_1_EG_1 6m8p_I_1_VG_1 6m8p_J_1_LH_1 6m8p_K_1_BI_1 6m8p_L_1_VI_1 6m8p_M_1_MJ_1 6m8p_N_1_EK_1 6m8p_O_1_UK_1 6m8p_P_1_LL_1 6m8p_Q_1_BM_1 6m8p_R_1_RM_1 6m8p_S_1_KN_1 6m8p_T_1_BO_1 6m8p_U_1_SO_1 6m8p_V_1_JP_1 6mgq_A_1_M_1 6mgq_B_1_O_1 6mgq_C_1_Q_1 6o5h_A_1_E_1 6o5h_B_1_G_1 6o5h_C_1_I_1 6oiu_A_1_E_1 6oiu_A_1_F_1 6oiu_B_1_J_1 6oiu_B_1_K_1 6oiu_C_1_O_1 6oiu_C_1_P_1 6oiu_D_1_T_1 6oiu_D_1_U_1 6q4r_A_1_F_1 6rqx_A_1_G_1 6ryf_A_1_E_1 6sbq_A_1_B_1 6sbr_A_1_B_1 6t6r_A_1_B_1 6u7e_A_1_I_1 6u7e_B_1_N_1 6u7f_A_1_I_1 6u7f_B_1_P_1 6u7g_A_1_I_1 6u7g_B_1_O_1 6ydx_A_1_K_1 6ydx_B_1_X_1 7auz_A_1_B_1 7av0_A_1_B_1 7av1_A_1_B_1 7av2_A_1_B_1 7kze_A_1_D_1 7kze_B_1_F_1 7kze_C_1_H_1 7llq_A_1_D_1 7llq_B_1_G_1 7llq_C_1_J_1 7nsk_A_1_M_1 7nsk_B_1_Y_1 7nup_A_1_T_1 7nup_B_1_LA_1 7nup_C_1_TA_1 7nup_D_1_BB_1 7p7p_A_1_BA_1 7p7p_B_1_KA_1 7pfs_A_1_V_1 7pfs_B_1_AA_1 7sh0_A_1_C_1 7sh0_B_1_I_1 7u0l_A_1_N_1 7v9n_A_1_B_1 7v9o_A_1_B_1 7v9p_A_1_C_1 7v9p_B_1_D_1 7v9q_A_1_B_1 7vpp_A_1_N_1 7vpp_C_1_U_1 7vpq_A_1_M_1 7vpq_C_1_U_1 7vpq_E_1_CA_1 7z28_A_1_D_1 7zyf_A_1_L_1 7zyf_B_1_W_1 8ava_A_1_B_1 8awh_A_1_B_1 8cgp_A_1_Z_1 8cgp_B_1_KA_1 8cgw_A_1_O_1 8cgw_B_1_AA_1 8ewz_A_1_H_1 8ex3_A_1_B_1 8eyd_A_1_D_1 8eye_A_1_M_1 8eyf_A_1_M_1 8ez2_A_1_K_1 8qow_A_1_B_1 8qpn_A_1_B_1 8qq4_A_1_B_1 8rx3_A_1_B_1 8rx7_A_1_B_1 8rx9_A_1_B_1 8slo_A_1_B_1 8sw0_A_1_B_1 8sw1_A_1_C_1 [NA ] 7sh0_A_1_H_1 precipitant [ACY ] 1h19_A_1_D_1 1sqm_A_1_E_1 4fyq_A_1_V_1 4fyq_A_2_V_2 [ACT ] 3ftw_A_1_E_1 3fty_A_1_F_1 3ftz_A_1_G_1 3fu0_A_1_F_1 3fu3_A_1_G_1 3fu6_A_1_F_1 4l2l_A_1_H_1 4rvb_A_1_E_1 5fwq_A_1_B_1 5lds_A_1_X_1 5lds_B_1_DA_1 5lds_C_1_KA_1 5lds_C_2_KA_2 5lds_D_1_QA_1 5lds_D_3_QA_3 5n3w_A_1_F_1 8ava_A_1_G_1 8awh_A_1_F_1 [ALA ] 4xmu_A_1_C_1 4xn8_A_1_C_1 [BAL ] 4xn9_A_1_C_1


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