Summary for the 292-nd Site(K)
PID QueryLength FocusSite TITLE
3025 967 292 K RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
UniProt Information
AC/IDAC:P15144 ID:AMPN_HUMAN
Feature Table for 292-th site MUTAGEN: /note="EKQ->NKT: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."
STRAND:
REGION: /note="Necessary and sufficient to mediate interaction with HCoV-229E" ECO:0000269|PubMed:8887485"
MUTAGEN: /note="DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."
REGION: /note="Metalloprotease"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Aminopeptidase N" /id="PRO_0000095081"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
A:17% D:10% R:9% G:9% S:9% T:9% V:8% K:7% N:6% E:6% L:5% I:3% H:1% P:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5lhd E (beta-strand) e (exposed) 46.7
3D Complex Information
Predicted Bind Molecules
hetero:2 otherpoly:8 compound:6 precipitant:3
Templates for 3D complexes
hetero [37515:SPIKE_CVH22 ] 6atk_A_1_E_1 [37516:SPIKE_CVH22 ] 6atk_B_1_D_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 4p8q_B_1_G_1 5c97_A_1_D_1 5c97_B_1_G_1 5lhd_B_1_N_1 5mj6_A_1_E_1 5mj6_B_1_O_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5lhd_C_1_U_1 5lhd_D_1_CA_1 compound [NAG ] 4pj6_B_1_Q_1 6atk_A_1_M_1 7vpp_A_1_S_1 7vpq_A_1_P_1 7vpq_C_1_X_1 7vpq_E_1_FA_1 precipitant [GOL ] 4zw3_A_1_D_1 4zx5_A_1_H_1 8eyf_A_1_H_1


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