Summary for the 289-th Site(Y)
PID QueryLength FocusSite TITLE
3025 967 289 Y RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
UniProt Information
AC/IDAC:P15144 ID:AMPN_HUMAN
Feature Table for 289-th site STRAND:
REGION: /note="Necessary and sufficient to mediate interaction with HCoV-229E" ECO:0000269|PubMed:8887485"
MUTAGEN: /note="DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."
REGION: /note="Metalloprotease"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Aminopeptidase N" /id="PRO_0000095081"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
Y:22% S:15% A:9% F:8% L:7% N:6% E:5% H:4% V:4% G:3% I:3% T:3% R:2% D:2% C:2% K:2% P:2% Q:1% M:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5lhd E (beta-strand) e (exposed) 39.6
3D Complex Information
Predicted Bind Molecules
hetero:9 homo:3 otherpoly:12 compound:6 precipitant:9
Templates for 3D complexes
hetero [37515:SPIKE_CVH22 ] 6atk_A_1_E_1 [37516:SPIKE_CVH22 ] 6atk_B_1_D_1 [37514:SPIKE_CVH22 ] 6atk_C_1_F_1 [37046 ] 6u7e_A_1_C_1 [37047 ] 6u7e_B_1_D_1 [37045 ] 6u7f_A_1_C_1 [36994 ] 6u7f_B_1_D_1 [37019:H1AG31_CVH22 ] 6u7g_A_1_C_1 6u7g_B_1_D_1 homo [97770:TRF3_THEAC ] 1z5h_B_3_A_2 1z5h_B_4_A_1 [99562:Q7Q2T8_ANOGA ] 4wz9_B_1_A_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 4p8q_A_1_D_1 4p8q_B_1_G_1 5c97_A_1_D_1 5c97_B_1_G_1 5mj6_A_1_E_1 5mj6_B_1_O_1 6ydx_B_1_G_1 7zyf_A_1_D_1 8cgp_A_1_D_1 8cgw_A_1_F_1 [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7pfs_A_1_G_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 8cgp_B_1_Q_1 compound [NAG ] 4pj6_B_1_Q_1 4z7i_A_1_N_1 4z7i_B_1_V_1 6ydx_A_1_N_1 7zyf_B_1_IA_1 8cgw_B_1_DA_1 precipitant [SO4 ] 1z5h_B_3_E_2 1z5h_B_4_E_1 [GOL ] 4zw3_A_1_D_1 4zx5_A_1_H_1 8eyf_A_1_H_1 [EDO ] 5ab0_A_1_Q_1 5lhd_B_1_EB_1 [FMT ] 6ifg_A_1_L_1 6ifg_B_1_P_1


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