Summary for the 288-th Site(D)
PID QueryLength FocusSite TITLE
3025 967 288 D RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
UniProt Information
AC/IDAC:P15144 ID:AMPN_HUMAN
Feature Table for 288-th site STRAND:
REGION: /note="Necessary and sufficient to mediate interaction with HCoV-229E" ECO:0000269|PubMed:8887485"
MUTAGEN: /note="DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."
REGION: /note="Metalloprotease"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Aminopeptidase N" /id="PRO_0000095081"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
D:21% E:16% K:11% T:7% V:7% R:6% Q:6% S:5% H:4% A:3% G:3% N:2% L:2% I:1% M:1% F:1% P:1% Y:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5lhd E (beta-strand) e (exposed) 42.6
3D Complex Information
Predicted Bind Molecules
hetero:9 homo:1 otherpoly:4 compound:1 precipitant:1
Templates for 3D complexes
hetero [37515:SPIKE_CVH22 ] 6atk_A_1_E_1 [37516:SPIKE_CVH22 ] 6atk_B_1_D_1 [37514:SPIKE_CVH22 ] 6atk_C_1_F_1 [37046 ] 6u7e_A_1_C_1 [37047 ] 6u7e_B_1_D_1 [37045 ] 6u7f_A_1_C_1 [36994 ] 6u7f_B_1_D_1 [37019:H1AG31_CVH22 ] 6u7g_A_1_C_1 6u7g_B_1_D_1 homo [99562:Q7Q2T8_ANOGA ] 4wz9_B_1_A_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5c97_A_1_D_1 8cgp_A_1_D_1 [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7pfs_A_1_G_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 7pfs_B_1_D_1 compound [NHE ] 4wz9_A_1_H_1 precipitant [EDO ] 5lhd_B_1_EB_1


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