Summary for the 358-th Site(D)
PID QueryLength FocusSite TITLE
13847 468 358 D RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 358-th site VARIANT: /note="D -> A (significantly associated with circulating levels of IL6 and soluble IL6R; increases cleavage by ADAM17; dbSNP:rs2228145)" ECO:0000269|PubMed:17357077, ECO:0000269|PubMed:28060820" /id="VAR_021995"
VAR_SEQ: /note="VQDSSSVPLP -> GSRRRGSCGL (in isoform 2)" ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8056053" /id="VSP_001682"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
VARIANT for 358-th site D->A LB/B dbSNP:rs2228145 " -"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
D:30% Q:21% H:21% E:14% G:14%


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