Summary for the 281-st Site(D)
PID QueryLength FocusSite TITLE
13847 468 281 D RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 281-th site MUTAGEN: /note="D->G: 70% decrease of ligand-binding and no IL6 signaling."
STRAND:
DOMAIN: /note="Fibronectin type-III 2"
CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
D:55% R:11% S:11% G:6% H:5% N:3% C:3% K:3% T:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1n26 S (bend) e (exposed) 39.5
3D Complex Information
Predicted Bind Molecules
hetero:25 homo:4
Templates for 3D complexes
hetero [69577:IL6RB_HUMAN ] 1p9m_C_1_A_1 1p9m_C_2_A_2 8dps_C_1_A_1 8dps_F_1_D_1 8dpu_C_1_A_1 8dpu_F_1_D_1 8dpu_I_1_G_1 8dpu_L_1_J_1 8dpu_O_1_M_1 8dpu_R_1_P_1 [47754:I27RA_HUMAN ] 7u7n_C_1_A_1 8d85_A_1_C_1 [72524:CNTFR_HUMAN ] 8d74_A_1_C_1 [94892:IL6RB_HUMAN ] 8d74_C_1_A_1 8d7r_B_1_D_1 [93862:IL6RB_HUMAN ] 8d82_A_1_C_1 8d82_D_1_F_1 [93942:IL6RB_HUMAN ] 8dpt_C_1_A_1 8dpt_F_1_D_1 [99335:IL6RB_MOUSE ] 8qy4_E_1_B_1 8qy4_F_1_D_1 8qy5_C_1_A_1 8qy5_E_1_F_1 8qy6_C_1_A_1 8qy6_E_1_F_1 homo [50645:PRLR_RAT ] 1f6f_B_1_C_1 [54602:PRLR_RAT ] 3ew3_B_1_C_1 [50646:PRLR_RAT ] 3npz_B_1_C_1 3npz_C_1_B_1


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