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| PID | QueryLength | FocusSite | TITLE |
| 13847 | 468 | 279 I | RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor; |
| AC/ID | AC:P08887 ID:IL6RA_HUMAN |
| Feature Table for 279-th site |
VARIANT: /note="I -> N (in HIES5; decreased STAT1 and STAT3 phosphorylation; dbSNP:rs1689606931)" /id="VAR_084713" MUTAGEN: /note="I->D: Complete loss of ligand-binding." STRAND: DOMAIN: /note="Fibronectin type-III 2" CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730" TOPO_DOM: /note="Extracellular" CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895" |
| VARIANT for 279-th site |
I->N LP/P dbSNP:rs1689606 " Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5) " [MIM:618944] |
Percentages of Amino Acids in Homologous Proteins
 [show alignment]
|
I:51% L:16% V:14% T:6% H:4% C:3% M:2% S:2% |
| Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
 1n26 |
E (beta-strand) | b (buried) | 0.0 |
| Predicted Bind Molecules |
| homo:3 |
| Templates for 3D complexes |
|
homo [50645:PRLR_RAT
] 1f6f_B_1_C_1 [54602:PRLR_RAT
] 3ew3_B_1_C_1 [50646:PRLR_RAT
] 3npz_B_1_C_1
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Summary for the 279-th Site(I)