Summary for the 278-th Site(V)
PID QueryLength FocusSite TITLE
13847 468 278 V RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 278-th site MUTAGEN: /note="V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling."
STRAND:
DOMAIN: /note="Fibronectin type-III 2"
CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
V:25% K:20% T:17% D:11% R:8% I:5% C:4% F:4% N:3% L:2%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1n26 E (beta-strand) e (exposed) 27.3
3D Complex Information
Predicted Bind Molecules
hetero:24 homo:4 precipitant:1
Templates for 3D complexes
hetero [48811:IL6RA_HUMAN ] 1p9m_A_1_C_1 1p9m_A_2_C_2 8qy5_A_1_C_1 8qy5_F_1_E_1 8qy6_A_1_C_1 8qy6_F_1_E_1 [47754:I27RA_HUMAN ] 7u7n_C_1_A_1 8d85_A_1_C_1 [72524:CNTFR_HUMAN ] 8d74_A_1_C_1 8d7r_D_1_B_1 [73261:IL6RA_HUMAN ] 8d82_C_1_A_1 8d82_F_1_D_1 [69392:I11RA_HUMAN ] 8dps_A_1_C_1 8dps_D_1_F_1 8qy4_B_1_E_1 8qy4_D_1_F_1 [69377:I11RA_HUMAN ] 8dpt_A_1_C_1 8dpt_D_1_F_1 8dpu_A_1_C_1 8dpu_D_1_F_1 8dpu_G_1_I_1 8dpu_J_1_L_1 8dpu_M_1_O_1 8dpu_P_1_R_1 homo [50645:PRLR_RAT ] 1f6f_B_1_C_1 [54602:PRLR_RAT ] 3ew3_B_1_C_1 [50646:PRLR_RAT ] 3npz_B_1_C_1 3npz_C_1_B_1 precipitant [SO4 ] 1bqu_B_1_J_1


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