Summary for the 277-th Site(C)
PID QueryLength FocusSite TITLE
13847 468 277 C RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 277-th site MUTAGEN: /note="C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling."
STRAND:
DOMAIN: /note="Fibronectin type-III 2"
CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
C:19% F:17% T:14% E:7% H:7% K:7% L:6% Y:6% S:5% A:4% I:3% R:1% N:1% D:1% Q:1% G:1% P:1% V:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1n26 E (beta-strand) b (buried) 11.3
3D Complex Information
Predicted Bind Molecules
hetero:19 precipitant:1
Templates for 3D complexes
hetero [48811:IL6RA_HUMAN ] 1p9m_A_1_C_1 1p9m_A_2_C_2 8qy5_A_1_C_1 8qy5_F_1_E_1 8qy6_A_1_C_1 [72524:CNTFR_HUMAN ] 8d74_A_1_C_1 8d7r_D_1_B_1 [69392:I11RA_HUMAN ] 8dps_A_1_C_1 8dps_D_1_F_1 8qy4_B_1_E_1 8qy4_D_1_F_1 [69377:I11RA_HUMAN ] 8dpt_A_1_C_1 8dpt_D_1_F_1 8dpu_A_1_C_1 8dpu_D_1_F_1 8dpu_G_1_I_1 8dpu_J_1_L_1 8dpu_M_1_O_1 8dpu_P_1_R_1 precipitant [SO4 ] 1bqu_B_1_J_1


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