Summary for the 233-rd Site(W)
PID QueryLength FocusSite TITLE
13847 468 233 W RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 233-th site MUTAGEN: /note="W->Q: 30% decrease of ligand-binding and increase of IL6 signaling."
DOMAIN: /note="Fibronectin type-III 2"
CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
Q:25% R:24% Y:17% W:12% I:9% H:6% T:3%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1n26 (coil) e (exposed) 31.9
3D Complex Information
Predicted Bind Molecules
hetero:32 homo:1
Templates for 3D complexes
hetero [69577:IL6RB_HUMAN ] 1p9m_C_1_A_1 1p9m_C_2_A_2 8dps_C_1_A_1 8dps_F_1_D_1 8dpu_C_1_A_1 8dpu_F_1_D_1 8dpu_L_1_J_1 8dpu_O_1_M_1 8dpu_R_1_P_1 [72524:CNTFR_HUMAN ] 8d74_A_1_C_1 8d7r_D_1_B_1 [94892:IL6RB_HUMAN ] 8d74_C_1_A_1 [93862:IL6RB_HUMAN ] 8d82_A_1_C_1 8d82_D_1_F_1 [73261:IL6RA_HUMAN ] 8d82_C_1_A_1 8d82_F_1_D_1 [69392:I11RA_HUMAN ] 8dps_A_1_C_1 8dps_D_1_F_1 8qy4_B_1_E_1 8qy4_D_1_F_1 [93942:IL6RB_HUMAN ] 8dpt_C_1_A_1 8dpt_F_1_D_1 [99335:IL6RB_MOUSE ] 8qy4_E_1_B_1 8qy4_F_1_D_1 8qy5_C_1_A_1 8qy5_E_1_F_1 8qy6_C_1_A_1 8qy6_E_1_F_1 [48811:IL6RA_HUMAN ] 8qy5_A_1_C_1 8qy5_F_1_E_1 8qy6_A_1_C_1 8qy6_F_1_E_1 homo [73261:IL6A_HUMAN ] 1n26_A_2_A_1


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