Summary for the 190-th Site(V)
PID QueryLength FocusSite TITLE
13847 468 190 V RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
UniProt Information
AC/IDAC:P08887 ID:IL6RA_HUMAN
Feature Table for 190-th site MUTAGEN: /note="V->G: 80% decrease of ligand-binding and no IL6 signaling."
STRAND:
DOMAIN: /note="Fibronectin type-III 1"
CHAIN: /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
V:37% I:22% E:18% N:6% A:5% L:5% T:3% M:2%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1n26 E (beta-strand) b (buried) 0.0
3D Complex Information
Predicted Bind Molecules
hetero:19 otherpoly:7 precipitant:1
Templates for 3D complexes
hetero [44979:Q98823_HHV8 ] 1i1r_A_1_B_1 1i1r_A_2_B_2 [42005:IL6_HUMAN ] 1p9m_A_1_B_1 1p9m_A_2_B_2 8d82_C_1_B_1 8d82_F_1_E_1 [40398:LIF_HUMAN ] 1pvh_A_1_B_1 1pvh_C_1_D_1 8d6a_B_1_A_1 [51762:CNTF_HUMAN ] 8d74_A_1_B_1 [42575:IL11_HUMAN ] 8dps_A_1_B_1 8dps_D_1_E_1 8dpt_A_1_B_1 8dpt_D_1_E_1 8dpu_A_1_B_1 8dpu_D_1_E_1 8dpu_G_1_H_1 8dpu_J_1_K_1 8dpu_M_1_N_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 6o4p_B_1_D_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 8dpu_C_1_T_1 8dpu_F_1_V_1 8dpu_I_1_X_1 8dpu_L_1_Z_1 8dpu_O_1_BA_1 8dpu_R_1_DA_1 precipitant [CO3 ] 3d48_B_1_F_1


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