Summary for the 189-th Site(V)
PID QueryLength FocusSite TITLE
27558 918 189 V RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
UniProt Information
AC/IDAC:P40189 ID:IL6RB_HUMAN
Feature Table for 189-th site MUTAGEN: /note="V->G: Does not induce ligand-independent activation."
VARIANT: /note="Missing (in IMD94; results in constitutively active IL6-mediated signaling and constitutive phosphorylation of STAT3 in patient cells)" /id="VAR_086950"
MUTAGEN: /note="Missing: Induces ligand-independent activation."
DOMAIN: /note="Fibronectin type-III 1"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit beta" /id="PRO_0000010899"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
I:21% V:15% L:14% T:9% E:6% S:6% A:5% Q:5% C:4% D:3% G:3% K:3% R:2% F:2% M:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
8d82 (coil) e (exposed) 37.3
3D Complex Information
Predicted Bind Molecules
hetero:20 homo:1
Templates for 3D complexes
hetero [45023:Q98823_HHV8 ] 1i1r_A_1_B_1 1i1r_A_2_B_2 [52193:CNTF_HUMAN ] 8d74_A_1_B_1 [42194:IL6_HUMAN ] 8d82_C_1_B_1 8d82_F_1_E_1 8qy5_A_1_B_1 8qy5_F_1_D_1 8qy6_A_1_B_1 8qy6_F_1_D_1 [42785:IL11_HUMAN ] 8dps_A_1_B_1 8dps_D_1_E_1 8dpt_A_1_B_1 8dpt_D_1_E_1 8dpu_A_1_B_1 8dpu_D_1_E_1 8dpu_G_1_H_1 8dpu_J_1_K_1 8dpu_M_1_N_1 8qy4_B_1_A_1 8qy4_D_1_C_1 homo [48861:IL6RB_HUMAN ] 1bqu_A_1_B_1


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