Summary for the 832-nd Site(E)

PID QueryLength FocusSite TITLE
27906 918 832 E RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
UniProt Information
AC/IDAC:P40189 ID:IL6RB_HUMAN
Feature Table for 832-th site MUTAGEN: /note="Missing: Results in impaired cytokine-mediated signaling pathway with loss of response to IL-6 and IL-11. Weak response to IL-27, OSM and LIF."
VARIANT: /note="Missing (in HIES4A; results in impaired cytokine- mediated signaling pathway with loss of response to IL-6, IL-11, OSM, LIF and a weak response to IL-27)" /id="VAR_086955"
VARIANT: /note="Missing (in HIES4A; results in impaired cytokine- mediated signaling pathway with loss of response to IL-6, IL-11, OSM and LIF and a weak response to IL-27)" /id="VAR_086954"
VARIANT: /note="Missing (in HIES4A; results in impaired cytokine- mediated signaling pathway with loss of response to IL-6, IL-11, OSM and LIF and a weak response to IL-27)" /id="VAR_086953"
TOPO_DOM: /note="Cytoplasmic"
VAR_SEQ: /note="Missing (in isoform 2)" /id="VSP_001685"
VARIANT: /note="Missing (in STWS2; results in impaired cytokine- mediated signaling pathway with loss of response to IL-6, IL-11, IL-27, OSM and LIF; does not localize to the cell membrane)" /id="VAR_086951"
CHAIN: /note="Interleukin-6 receptor subunit beta" /id="PRO_0000010899"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment]
E:68% G:32% 


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