Summary for the 187-th Site(S)
PID QueryLength FocusSite TITLE
27906 918 187 S RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
UniProt Information
AC/IDAC:P40189 ID:IL6RB_HUMAN
Feature Table for 187-th site VARIANT: /note="Missing (in IMD94; results in constitutively active IL6-mediated signaling and constitutive phosphorylation of STAT3 in patient cells)" /id="VAR_086950"
MUTAGEN: /note="Missing: Induces ligand-independent activation."
DOMAIN: /note="Fibronectin type-III 1"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit beta" /id="PRO_0000010899"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
D:12% L:12% Q:11% S:10% T:10% G:7% N:6% K:6% E:5% A:4% M:3% V:3% R:2% H:2% F:2% P:2% Y:2% C:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
8d82 (coil) e (exposed) 78.9
3D Complex Information
Predicted Bind Molecules
hetero:39 homo:1 otherpoly:2 compound:2 metal:7 precipitant:1
Templates for 3D complexes
hetero [45023:Q98823_HHV8 ] 1i1r_A_1_B_1 1i1r_A_2_B_2 [42194:IL6_HUMAN ] 1p9m_A_1_B_1 1p9m_A_2_B_2 5fuc_C_1_B_1 8d82_C_1_B_1 8d82_F_1_E_1 8qy5_A_1_B_1 8qy5_F_1_D_1 8qy6_A_1_B_1 8qy6_F_1_D_1 [40397:LIF_HUMAN ] 1pvh_A_1_B_1 1pvh_C_1_D_1 [46475:PRL_HUMAN ] 3d48_B_1_A_1 [49171:PRL_HUMAN ] 3ew3_B_1_A_1 [45993:PRL_HUMAN ] 3npz_B_1_A_1 [42141:IL6_HUMAN ] 5fuc_D_1_A_1 [36225:LEP_MOUSE ] 7z3r_B_1_A_1 7z3r_B_2_A_2 7z3r_B_3_A_3 8b7q_B_1_A_1 [37484:LEP_HUMAN ] 8avf_B_1_A_1 8avo_B_1_A_1 8avo_F_1_E_1 [52193:CNTF_HUMAN ] 8d74_C_1_B_1 [49527:CLCF1_HUMAN ] 8d7h_A_1_B_1 8d7h_C_1_B_1 8d7h_D_1_E_1 8d7h_F_1_E_1 8d7r_B_1_A_1 8d7r_D_1_A_1 [42785:IL11_HUMAN ] 8dps_A_1_B_1 8dps_D_1_E_1 8dpt_A_1_B_1 8dpt_D_1_E_1 8dpu_A_1_B_1 8dpu_C_1_B_1 8dpu_D_1_E_1 8dpu_J_1_K_1 homo [48861:IL6RB_HUMAN ] 1bqu_A_1_B_1 otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ] 2q7n_A_1_I_1 2q7n_C_1_O_1 compound [CYS ] 1n26_A_1_H_1 1n26_A_2_H_2 metal [NA ] 3mzg_B_1_C_1 3n06_B_1_C_1 3n0p_B_1_D_1 3ncb_B_1_E_1 3ncc_B_1_D_1 3nce_B_1_G_1 3ncf_B_1_D_1 precipitant [GOL ] 1bqu_B_1_M_1


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