Summary for the 290-th Site(V)
PID QueryLength FocusSite TITLE
3025 967 290 V RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
UniProt Information
AC/IDAC:P15144 ID:AMPN_HUMAN
Feature Table for 290-th site STRAND:
REGION: /note="Necessary and sufficient to mediate interaction with HCoV-229E" ECO:0000269|PubMed:8887485"
MUTAGEN: /note="DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection."
MUTAGEN: /note="DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."
REGION: /note="Metalloprotease"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Aminopeptidase N" /id="PRO_0000095081"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
V:22% I:21% L:11% S:8% R:7% A:6% K:6% E:4% F:3% D:2% G:2% P:2% T:2% N:1% C:1% Q:1% H:1% M:1% Y:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5lhd E (beta-strand) b (buried) 18.0
3D Complex Information
Predicted Bind Molecules
hetero:9
Templates for 3D complexes
hetero [37412:SPIKE_CVH22 ] 6atk_A_1_E_1 [37424:SPIKE_CVH22 ] 6atk_B_1_D_1 [37496:SPIKE_CVH22 ] 6atk_C_1_F_1 [37287 ] 6u7e_A_1_C_1 [37286 ] 6u7e_B_1_D_1 [37285 ] 6u7f_A_1_C_1 [37223 ] 6u7f_B_1_D_1 [37248:H1AG31_CVH22 ] 6u7g_A_1_C_1 6u7g_B_1_D_1


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