Summary for the 40-th Site(F)
PID QueryLength FocusSite TITLE
31681 805 40 F RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor;
UniProt Information
AC/IDAC:Q9BYF1 ID:ACE2_HUMAN
Feature Table for 40-th site MUTAGEN: /note="F->D: Increases slightly the interaction with RBD domain of SARS-CoV-2 spike protein."
REGION: /note="Interaction with SARS-CoV spike glycoprotein"
HELIX:
VAR_SEQ: /note="MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNT NITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSED KSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS EVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHT FEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK PNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPT AWDLGKGDF -> MREAGWDKGG (in isoform 2)" /id="VSP_060903"
DOMAIN: /note="Peptidase M2"
CHAIN: /note="Processed angiotensin-converting enzyme 2" /id="PRO_0000292268"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Angiotensin-converting enzyme 2" /id="PRO_0000028570"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
L:38% S:17% F:14% W:13% T:12% I:7%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
7v61 H (alpha-helix) e (exposed) 24.9
3D Complex Information
Predicted Bind Molecules
hetero:14 metal:1 precipitant:2
Templates for 3D complexes
hetero [9234 ] 8b9p_A_1_C_1 8b9p_B_1_D_1 [9325 ] 8bfw_A_1_B_1 8bfw_C_1_D_1 8byj_A_1_D_1 8byj_B_1_C_1 [10516 ] 8bn1_A_1_D_1 8bn1_B_1_C_1 [9509 ] 8toq_A_1_B_1 [9508 ] 8tor_A_1_B_1 8tot_A_1_C_1 8tot_B_1_D_1 8tou_A_1_B_1 [10110 ] 8tos_A_1_B_1 metal [CL ] 8df5_E_1_TA_1 precipitant [GOL ] 8asy_A_1_N_1 8asy_A_1_O_1


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