Summary for the 190-th Site(Y)
PID QueryLength FocusSite TITLE
7656 918 190 Y RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
UniProt Information
AC/IDAC:P40189 ID:IL6RB_HUMAN
Feature Table for 190-th site MUTAGEN: /note="Y->G: Does not induce ligand-independent activation."
STRAND:
VARIANT: /note="Missing (in IMD94; results in constitutively active IL6-mediated signaling and constitutive phosphorylation of STAT3 in patient cells)" /id="VAR_086950"
MUTAGEN: /note="Missing: Induces ligand-independent activation."
DOMAIN: /note="Fibronectin type-III 1"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit beta" /id="PRO_0000010899"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
Y:23% L:16% F:14% S:8% K:7% M:6% W:5% R:4% H:4% V:4% G:3% I:2% T:2%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
8d82 (coil) e (exposed) 22.6
3D Complex Information
Predicted Bind Molecules
hetero:85 metal:1 precipitant:1
Templates for 3D complexes
hetero [46714:SOMA_HUMAN ] 1bp3_B_1_A_1 [41484:CSF3_HUMAN ] 1cd9_B_1_A_1 1cd9_D_1_C_1 1pgr_B_1_A_1 1pgr_D_1_C_1 1pgr_F_1_E_1 1pgr_H_1_G_1 2d9q_B_1_A_1 2d9q_B_2_A_2 [48411:CSH_SHEEP ] 1f6f_B_1_A_1 1f6f_C_1_A_1 [45023:Q98823_HHV8 ] 1i1r_A_1_B_1 1i1r_A_2_B_2 [42194:IL6_HUMAN ] 1p9m_A_1_B_1 1p9m_A_2_B_2 8d82_C_1_B_1 8d82_F_1_E_1 8qy5_A_1_B_1 8qy5_F_1_D_1 8qy6_A_1_B_1 8qy6_F_1_D_1 [46475:PRL_HUMAN ] 3d48_B_1_A_1 [49171:PRL_HUMAN ] 3ew3_B_1_A_1 3ew3_C_1_A_1 [45993:PRL_HUMAN ] 3mzg_B_1_A_1 3n06_B_1_A_1 3n0p_B_1_A_1 3ncb_B_1_A_1 3ncc_B_1_A_1 3nce_B_1_A_1 3ncf_B_1_A_1 3npz_B_1_A_1 3npz_C_1_A_1 [54681 ] 3v6o_A_1_C_1 [43070:LEP_HUMAN ] 7z3q_B_1_C_1 7z3q_D_1_A_1 7z3q_F_1_E_1 [36225:LEP_MOUSE ] 7z3r_B_1_A_1 7z3r_B_2_A_2 7z3r_B_3_A_3 8avb_B_1_A_1 8avc_B_1_A_1 8avc_D_1_C_1 8avc_F_1_E_1 8avd_B_1_A_1 8avd_D_1_C_1 8avd_F_1_E_1 8b7q_B_1_A_1 8dh9_A_1_D_1 8dh9_B_1_C_1 8dha_B_1_C_1 [37484:LEP_HUMAN ] 8ave_B_1_A_1 8ave_D_1_C_1 8avf_B_1_A_1 8avf_D_1_C_1 8avf_F_1_E_1 8avo_B_1_A_1 8avo_D_1_C_1 8avo_F_1_E_1 [40397:LIF_HUMAN ] 8d6a_B_1_A_1 [52193:CNTF_HUMAN ] 8d74_A_1_B_1 8d74_C_1_B_1 [49527:CLCF1_HUMAN ] 8d7h_A_1_B_1 8d7h_C_1_B_1 8d7h_D_1_E_1 8d7h_F_1_E_1 8d7r_B_1_A_1 8d7r_D_1_A_1 [42785:IL11_HUMAN ] 8dps_A_1_B_1 8dps_D_1_E_1 8dpt_A_1_B_1 8dpt_C_1_B_1 8dpt_D_1_E_1 8dpt_F_1_E_1 8dpu_A_1_B_1 8dpu_C_1_B_1 8dpu_D_1_E_1 8dpu_F_1_E_1 8dpu_G_1_H_1 8dpu_I_1_H_1 8dpu_J_1_K_1 8dpu_L_1_K_1 8dpu_M_1_N_1 8dpu_O_1_N_1 8dpu_R_1_Q_1 metal [NA ] 3nce_B_1_C_1 precipitant [ACT ] 3v6o_A_1_V_1


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