Summary for the 189-th Site(V)
PID QueryLength FocusSite TITLE
845549 918 189 V RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
UniProt Information
AC/IDAC:P40189 ID:IL6RB_HUMAN
Feature Table for 189-th site MUTAGEN: /note="V->G: Does not induce ligand-independent activation."
VARIANT: /note="Missing (in IMD94; results in constitutively active IL6-mediated signaling and constitutive phosphorylation of STAT3 in patient cells)" /id="VAR_086950"
MUTAGEN: /note="Missing: Induces ligand-independent activation."
DOMAIN: /note="Fibronectin type-III 1"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Interleukin-6 receptor subunit beta" /id="PRO_0000010899"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
I:21% V:15% L:14% T:9% E:6% S:6% A:5% Q:5% C:4% D:3% G:3% K:3% R:2% F:2% M:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
8d82 (coil) e (exposed) 36.0
3D Complex Information
Predicted Bind Molecules
hetero:104 homo:1
Templates for 3D complexes
hetero [47862:SOMA_HUMAN ] 1bp3_B_1_A_1 [42479:CSF3_HUMAN ] 1cd9_B_1_A_1 1cd9_D_1_C_1 1pgr_B_1_A_1 1pgr_D_1_C_1 1pgr_F_1_E_1 1pgr_H_1_G_1 2d9q_B_1_A_1 2d9q_B_2_A_2 [49618:CSH_SHEEP ] 1f6f_B_1_A_1 1f6f_C_1_A_1 [46056:Q98823_HHV8 ] 1i1r_A_1_B_1 1i1r_A_2_B_2 [71468:IL6RB_HUMAN ] 1p9m_C_1_A_2 1p9m_C_2_A_1 [42965:IL6_HUMAN ] 1p9m_C_1_B_1 1p9m_C_2_B_2 5fuc_C_1_B_1 8d82_A_1_B_1 8d82_C_1_B_1 8d82_D_1_E_1 8d82_F_1_E_1 8qy5_A_1_B_1 8qy5_C_1_B_1 8qy5_E_1_D_1 8qy5_F_1_D_1 8qy6_A_1_B_1 8qy6_C_1_B_1 8qy6_E_1_D_1 8qy6_F_1_D_1 [47347:PRL_HUMAN ] 3d48_B_1_A_1 [50279:PRL_HUMAN ] 3ew3_B_1_A_1 3ew3_C_1_A_1 [47033:PRL_HUMAN ] 3mzg_B_1_A_1 3n06_B_1_A_1 3n0p_B_1_A_1 3ncb_B_1_A_1 3ncc_B_1_A_1 3nce_B_1_A_1 3ncf_B_1_A_1 3npz_B_1_A_1 3npz_C_1_A_1 [43196:LEP_HUMAN ] 7z3q_B_1_C_1 7z3q_D_1_A_1 7z3q_F_1_E_1 8x85_A_1_D_1 [36916:LEP_MOUSE ] 7z3r_B_1_A_1 7z3r_B_2_A_2 7z3r_B_3_A_3 8avb_B_1_A_1 8avc_B_1_A_1 8avc_D_1_C_1 8avc_F_1_E_1 8avd_B_1_A_1 8avd_D_1_C_1 8avd_F_1_E_1 8b7q_B_1_A_1 8dh8_B_1_C_1 8dh9_A_1_D_1 8dh9_B_1_C_1 [38197:LEP_HUMAN ] 8ave_B_1_A_1 8ave_D_1_C_1 8avf_B_1_A_1 8avf_D_1_C_1 8avo_B_1_A_1 8avo_D_1_C_1 8avo_F_1_E_1 8x80_B_1_C_1 8x80_E_1_F_1 8x81_B_1_D_1 8x81_F_1_E_1 8x85_B_1_C_1 [53229:CNTF_HUMAN ] 8d74_A_1_B_1 8d74_C_1_B_1 [50640:CLCF1_HUMAN ] 8d7h_A_1_B_1 8d7h_C_1_B_1 8d7h_D_1_E_1 8d7h_F_1_E_1 8d7r_B_1_A_1 [96536:IL6RB_HUMAN ] 8d82_A_1_F_1 8d82_D_1_C_1 [43559:IL11_HUMAN ] 8dps_A_1_B_1 8dps_D_1_E_1 8dpt_A_1_B_1 8dpt_C_1_B_1 8dpt_D_1_E_1 8dpt_F_1_E_1 8dpu_A_1_B_1 8dpu_C_1_B_1 8dpu_D_1_E_1 8dpu_F_1_E_1 8dpu_G_1_H_1 8dpu_I_1_H_1 8dpu_J_1_K_1 8dpu_L_1_K_1 8dpu_M_1_N_1 8dpu_O_1_N_1 8dpu_R_1_Q_1 8qy4_B_1_A_1 8qy4_D_1_C_1 [102291:IL6RB_MOUSE ] 8qy6_C_1_F_1 8qy6_E_1_A_1 [16166 ] 8upa_B_1_A_1 8upa_D_1_C_1 homo [49948:IL6RB_HUMAN ] 1bqu_A_1_B_1


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