Summary for the 252-nd Site(L)
PID QueryLength FocusSite TITLE
2993159 296 252 L RecName: Full=Myeloid differentiation primary response protein MyD88 ;
UniProt Information
AC/IDAC:Q99836 ID:MYD88_HUMAN
Feature Table for 252-th site VARIANT: /note="L -> P (in WM1; uncertain significance; somatic mutation; constitutively activates NF-kappaB complex activation; gain-of-function mutation; does not affect interaction with IRAK4; dbSNP:rs387907272)" ECO:0000269|PubMed:22931316, ECO:0000269|PubMed:24366360" /id="VAR_073262"
STRAND:
DOMAIN: /note="TIR"
VAR_SEQ: /note="HMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSI ASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPS ILRFITVCDYTNPCTKSWFWTRLAKALSLP -> AAGWWWLSLMITCRARNVTSRPNLH SASLQVPIRSD (in isoform 3 and isoform 4)" /id="VSP_043500"
CHAIN: /note="Myeloid differentiation primary response protein MyD88" /id="PRO_0000096666"
VARIANT for 252-th site L->P US dbSNP:rs3879072 " Macroglobulinemia, Waldenstrom, 1 (WM1) " [MIM:153600]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
L:52% I:28% T:12% V:9%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
2js7 E (beta-strand) b (buried) 0.0


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