Summary for the 185-th Site(D)
PID QueryLength FocusSite TITLE
2931865 365 185 D RecName: Full=HLA class I histocompatibility antigen, A alpha chain;AltName: Full=Human leukocyte antigen A; Short=HLA-A;Flags: Precursor;
UniProt Information
AC/IDAC:P04439 ID:HLAA_HUMAN
Feature Table for 185-th site VARIANT: /note="D -> E (in allele A*01:01, allele A*02:01, allele A*02:05, allele A*11:01, allele A*23:01, allele A*24:02, allele A*25:01, allele A*26:01, allele A*29:02, allele A*30:01, allele A*31:01, allele A*32:01, allele A*33:01, allele A*34:01, allele A*36:01, allele A*43:01, allele A*66:01, allele A*68:01, allele A*69:01, allele A*74:01 and allele A*80:01; dbSNP:rs1059542)" ECO:0000269|PubMed:1431115, ECO:0000269|PubMed:1729171, ECO:0000269|PubMed:1782566, ECO:0000269|PubMed:2251137, ECO:0000269|PubMed:2320591, ECO:0000269|PubMed:2431040, ECO:0000269|PubMed:2437024, ECO:0000269|PubMed:2460344, ECO:0000269|PubMed:2478623, ECO:0000269|PubMed:2715640, ECO:0000269|PubMed:2982951, ECO:0000269|PubMed:3496393, ECO:0000269|PubMed:3877632, ECO:0000269|PubMed:7836067, ECO:0000269|PubMed:7871528, ECO:0000269|PubMed:8016845, ECO:0000269|PubMed:8026990, ECO:0000269|PubMed:8188325, ECO:0000269|PubMed:8284791, ECO:0000269|PubMed:8475492, ECO:0000269|PubMed:8795145, ECO:0000269|PubMed:9349616, ECO:0000269|PubMed:9349617, ECO:0000269|Ref.29" /id="VAR_082377"
VAR_SEQ: /note="EAEQLRAYLDGT -> AAEQQRAYLEGR (in isoform 2)" /id="VSP_060391"
REGION: /note="Alpha-2"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="HLA class I histocompatibility antigen, A alpha chain" /id="PRO_0000018815"
VARIANT for 185-th site D->E LB/B dbSNP:rs1059542 " -"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
D:33% E:25% S:10% N:7% L:5% K:4% R:3% Q:3% H:3% T:3% G:2% Y:2%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
6o9c H (alpha-helix) e (exposed) 37.7
3D Complex Information
Predicted Bind Molecules
hetero:44 homo:1 compound:1 precipitant:22
Templates for 3D complexes
hetero [49750 ] 2ak4_K_1_N_1 2ak4_P_1_S_1 3kxf_A_1_D_1 3kxf_C_1_G_1 3kxf_I_1_K_1 4jrx_A_1_D_1 [48786 ] 2ypl_A_1_D_1 [48047 ] 4mji_A_1_D_1 4mji_F_1_I_1 [48925:H2RG00_PANTR :K7N5M9_HUMAN ] 4mnq_A_1_D_1 [50234 ] 4qrp_A_1_D_1 4qrp_F_1_J_1 [55665 ] 4wuu_A_1_E_1 [50568:K7N5M3_HUMAN ] 5e6i_H_1_F_1 5e6i_R_1_P_1 [52029 ] 5jhd_A_1_D_1 [49412:A0A0B4J268_HUMAN ] 6avg_D_1_B_1 6avg_H_1_F_1 [63704 ] 6d7g_A_2_C_1 [47915:TVA22_HUMAN :K7N5M3_HUMAN ] 6r2l_A_1_D_1 [50673 ] 6tro_A_1_D_1 [48613 ] 7byd_A_1_D_1 7byd_F_1_I_1 [47435 ] 7nme_A_1_D_1 7nmf_A_1_D_1 7nmg_A_1_D_1 [62367 ] 7phr_F_1_A_1 [46903 ] 7q9b_F_1_D_1 [55181 ] 8eb2_A_1_L_1 8eb2_D_1_J_1 [54470 ] 8eb2_A_1_M_1 8eb2_D_1_K_1 8eb2_G_1_O_1 [50049 ] 8en8_A_1_D_1 8en8_F_1_I_1 8enh_A_1_D_1 8enh_F_1_I_1 8enh_K_1_N_1 8enh_P_1_S_1 8eo8_A_1_D_1 8eo8_F_1_I_1 8eo8_K_1_N_1 8eo8_P_1_S_1 [47796 ] 8i5d_C_1_A_1 homo [66778:A3F718_HUMAN ] 3dtx_A_2_A_1 compound [PE8 ] 6z9v_D_1_Z_1 precipitant [SO4 ] 2pye_A_1_G_1 4jfd_A_1_J_1 5c0i_A_1_L_1 5c0j_A_1_I_1 5eu4_A_1_K_1 6uj9_A_1_K_1 [GOL ] 3d3v_A_1_G_1 4gks_D_1_T_1 5eu5_A_1_V_1 7pbc_A_1_H_1 7qpj_A_1_I_1 [EDO ] 4zfz_A_1_V_1 6iwg_A_1_H_1 6lah_C_1_AA_1 6lb2_A_1_V_1 6r2l_A_1_G_1 7wt3_A_1_Z_1 7wt4_A_1_BA_1 7wt5_D_1_BB_1 8rhq_A_1_L_1 [PEG ] 5wsh_A_1_D_1 7re8_E_1_T_1


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