Summary for the 185-th Site(D)

PID QueryLength FocusSite TITLE
2931865 365 185 D RecName: Full=HLA class I histocompatibility antigen, A alpha chain;AltName: Full=Human leukocyte antigen A; Short=HLA-A;Flags: Precursor;
UniProt Information
AC/IDAC:P04439 ID:HLAA_HUMAN
Feature Table for 185-th site VARIANT: /note="D -> E (in allele A*01:01, allele A*02:01, allele A*02:05, allele A*11:01, allele A*23:01, allele A*24:02, allele A*25:01, allele A*26:01, allele A*29:02, allele A*30:01, allele A*31:01, allele A*32:01, allele A*33:01, allele A*34:01, allele A*36:01, allele A*43:01, allele A*66:01, allele A*68:01, allele A*69:01, allele A*74:01 and allele A*80:01; dbSNP:rs1059542)" ECO:0000269|PubMed:1431115, ECO:0000269|PubMed:1729171, ECO:0000269|PubMed:1782566, ECO:0000269|PubMed:2251137, ECO:0000269|PubMed:2320591, ECO:0000269|PubMed:2431040, ECO:0000269|PubMed:2437024, ECO:0000269|PubMed:2460344, ECO:0000269|PubMed:2478623, ECO:0000269|PubMed:2715640, ECO:0000269|PubMed:2982951, ECO:0000269|PubMed:3496393, ECO:0000269|PubMed:3877632, ECO:0000269|PubMed:7836067, ECO:0000269|PubMed:7871528, ECO:0000269|PubMed:8016845, ECO:0000269|PubMed:8026990, ECO:0000269|PubMed:8188325, ECO:0000269|PubMed:8284791, ECO:0000269|PubMed:8475492, ECO:0000269|PubMed:8795145, ECO:0000269|PubMed:9349616, ECO:0000269|PubMed:9349617, ECO:0000269|Ref.29" /id="VAR_082377"
VAR_SEQ: /note="EAEQLRAYLDGT -> AAEQQRAYLEGR (in isoform 2)" /id="VSP_060391"
REGION: /note="Alpha-2"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="HLA class I histocompatibility antigen, A alpha chain" /id="PRO_0000018815"
VARIANT for 185-th site D->E LB/B dbSNP:rs1059542 " -"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment]
D:33% E:25% S:10% N:7% L:5% K:4% R:3% Q:3% H:3% T:3% G:2% Y:2% 
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
8dvg T (Hbond turn) e (exposed) 35.2


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