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| PID | QueryLength | FocusSite | TITLE |
| 2931865 | 365 | 176 E | RecName: Full=HLA class I histocompatibility antigen, A alpha chain;AltName: Full=Human leukocyte antigen A; Short=HLA-A;Flags: Precursor; |
| AC/ID | AC:P04439 ID:HLAA_HUMAN |
| Feature Table for 176-th site |
VARIANT: /note="E -> A (in allele A*01:01, allele A*11:01 and allele A*36:01)" ECO:0000269|PubMed:2251137, ECO:0000269|PubMed:2437024, ECO:0000269|PubMed:2460344, ECO:0000269|PubMed:2715640, ECO:0000269|PubMed:8016845, ECO:0000269|PubMed:9349617" /id="VAR_082369" VARIANT: /note="E -> R (in allele A*80:01; requires 2 nucleotide substitutions)" ECO:0000269|PubMed:8284791" /id="VAR_082370" VARIANT: /note="E -> V (in allele A*02:01, allele A*02:05, allele A*23:01, allele A*24:02, allele A*29:02, allele A*31:01, allele A*32:01, allele A*33:01, allele A*68:01, allele A*69:01 and allele A*74:01; results in inefficient T cell recognition of epitopes derived from influenza A virus.; dbSNP:rs9256983)" ECO:0000269|PubMed:1431115, ECO:0000269|PubMed:1729171, ECO:0000269|PubMed:1782566, ECO:0000269|PubMed:2320591, ECO:0000269|PubMed:2431040, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:2478623, ECO:0000269|PubMed:2982951, ECO:0000269|PubMed:3496393, ECO:0000269|PubMed:3877632, ECO:0000269|PubMed:7836067, ECO:0000269|PubMed:8795145, ECO:0000269|PubMed:9349616, ECO:0000269|Ref.29" /id="VAR_082371" VARIANT: /note="E -> W (in allele A*30:01; requires 2 nucleotide substitutions)" ECO:0000269|PubMed:7871528" /id="VAR_082372" HELIX: VAR_SEQ: /note="EAEQLRAYLDGT -> AAEQQRAYLEGR (in isoform 2)" /id="VSP_060391" REGION: /note="Alpha-2" TOPO_DOM: /note="Extracellular" CHAIN: /note="HLA class I histocompatibility antigen, A alpha chain" /id="PRO_0000018815" |
| VARIANT for 176-th site |
E->A LB/B " -" E->R LB/B " -" E->V LB/B dbSNP:rs9256983 " -" E->W LB/B " -" |
Percentages of Amino Acids in Homologous Proteins
 [show alignment]
|
E:31% D:14% I:9% R:7% K:7% Y:7% G:5% T:5% A:4% Q:4% F:2% V:2% L:1% W:1% |
| Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
 8dvg |
H (alpha-helix) | e (exposed) | 41.2 |
| Predicted Bind Molecules |
| hetero:15 precipitant:1 |
| Templates for 3D complexes |
|
hetero [1725:MYPR_HUMAN
] 2xpg_A_1_C_1 [2108:Q9YV12_9HIV1
] 3rl1_A_1_C_1 [2739:Q9YYU8_9HIV1
] 3rl2_A_1_C_1 [1747:PK3CA_HUMAN
] 7l1b_A_1_C_1 [2045:PK3CA_HUMAN
] 7l1c_A_1_C_1 7l1d_A_2_C_2 7rrg_A_1_E_1 [50155 ] 7l1d_A_2_D_1 [61969 ] 7l1d_A_2_E_1 [1938:NCAP_INBAC
] 7mle_A_1_C_1 [50433 ] 7rrg_A_1_C_2 [2536 ] 7stf_D_1_B_1 [1943:NCAP_I46A1
] 7uc5_A_1_C_1 7uc5_D_1_F_1 [2966 ] 8dvg_A_1_C_1
precipitant [SO4 ] 8dvg_A_1_G_1
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Summary for the 176-th Site(E)